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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653240/
Apr 08, 2013 · Introduction. Mice must be acclimated to handling for a period of two-four weeks before the onset of intranasal dosing. Acclimation to handling is important, as it helps ensure a correct body position for maximum effectiveness of awake intranasal drug delivery.Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
https://www.youtube.com/watch?v=u2F6UU0dQw0
Jan 27, 2015 · Intranasal infection of mice Dilini Ranatunga ... How and Why to Use Intranasal Medications - Duration: 2:02. Graham Walker 15,217 views. 2:02. Intranasal spray administration on mice - Duration ...Author: Dilini Ranatunga
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
https://www.sciencedirect.com/science/article/pii/S0361923018303678
In the study of Westin et al. the received volume of the intranasal administration is 5 μl for mice and 50 μl for rats and the drug was administered into the right nostril (right-sided administration), so the left olfactory bulb could serve as a control (Westin et al., 2005). It is important to keep the animals in a supine position in order ...Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://www.jove.com/video/4440/intranasal-administration-of-cns-therapeutics-to-awake-mice
4. General Animal Handling Techniques for Acclimation and Intranasal Delivery of Drug to Awake Mice. After each acclimation or intranasal dosing session, mice should be given a treat, such as a Cheerio or peeled sunflower seed as positive reinforcement.Author: Leah R. Hanson, Jared M. Fine, Aleta L. Svitak, Katherine A. Faltesek
https://www.youtube.com/watch?v=ny_MVCnkLRc
Jun 30, 2016 · "The truth about mobile phone and wireless radiation" -- Dr Devra Davis - Duration: 1:01:30. The University of Melbourne Recommended for you
https://www.sciencedirect.com/science/article/pii/S0168365916301079
Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways. ... Thus, overcoming the nasal epithelial barrier is the key to achieve enhanced immune responses. ... Intranasal inoculation of mice with CP 2k/mRNA led to strong mucosal and systemic immune responses in a balanced Th1 ...Author: Man Li, Mengnan Zhao, Yao Fu, You Li, Tao Gong, Zhirong Zhang, Xun Sun
https://www.researchgate.net/post/Dear_colleagues_please_tell_us_how_to_do_intranasal_administration_to_mice_methodHow_to_minimize_animal_stress
Dear colleagues, please tell us how to do intranasal administration to mice (method)?How to minimize animal stress? ... 2ul for delivery to the upper airway, and 20ul for delivery to the lower ...
https://www.jove.com/video/58485/novel-methods-for-intranasal-administration-under-inhalation
1. Animals Used for Intranasal Administration Under Inhalation Anesthesia. House the experimental mice in stainless-steel cages under a 12-h light/dark cycle (light on 8:00 AM–8:00 PM), with a controlled temperature maintained at 23 ± 1°C, humidity of 50% ± 10%, and ad libitum access to food and water.Author: Takanori Kanazawa, Mitsuyoshi Fukuda, Naoto Suzuki, Toyofumi Suzuki
https://journals.physiology.org/doi/pdf/10.1152/ajplung.00173.2001
tion for the chosen volumes. Intranasal delivery is often carried out after intraperitoneal (9, 19) or inha-lation (5, 14, 15) anesthesia but has also been per-formed with fully awake mice (1, 6, 17). The position of the mouse during intranasal delivery has also varied between studies, with horizontal (13) and head-down
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