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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal insulin improves memory, attention, and functioning in patients with Alzheimer's disease or mild cognitive impairment, and even improves memory and mood in normal adult humans. This new method of delivery can revolutionize the treatment of Alzheimer's disease, stroke, and other brain disorders.Author: Leah R Hanson, William H Frey, William H Frey
https://www.sciencedirect.com/science/article/pii/S0304394019306706
Intranasal (IN) delivery of insulin has been shown to provide benefits to both animal models of neurodegenerative disease and humans in clinical trials. Intranasal delivery provides a means of bypassing the blood-brain barrier as drugs travel directly along the olfactory and trigeminal nerves to target the brain . This process can be facilitated by the use of a device that deposits drugs to the …Author: Jared M. Fine, Benjamin M. Stroebel, Katherine A. Faltesek, Kaoru Terai, Lucas Haase, Kristin E. Knu...
https://www.lostfalco.com/intranasal-insulin/
“Saline or insulin (Novolin R; Novo Nordisk, Princeton, New Jersey) was administered after breakfast and dinner with a ViaNase nasal drug delivery device…” Here’s the ViaNase. While something like the ViaNase might be nice other human studies on intranasal insulin have used spray bottles or droppers with very good results.
https://www.in-pharmatechnologist.com/Article/2004/12/13/Intranasal-delivery-of-insulin-shows-promise
Dec 13, 2004 · Intranasal delivery of insulin shows promise. injections with more patient-friendly options. The specialty pharmaceutical and drug delivery company, which has a growing branded and generic product line in Europe, reported the results of a Phase II trial of the formulation, called CPE-215, at the end of last week.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779219/
May 20, 2009 · The frequency of insulin delivery was optimized to best mimic clinical insulin nasal sprays previously marketed (Reviewed by Barnett, 2004; Dunn and Curran, 2006a,b). Mice were given intranasal insulin (I+), PBS (V), or boiled insulin (B) twice a day for five days before being subjected to behavioral tests on the sixth and seventh days of ...Author: David R. Marks, Kristal Tucker, Melissa A. Cavallin, Thomas G. Mast, Debra A. Fadool
https://www.alzforum.org/therapeutics/nasal-insulin
Intranasal insulin appeared safe in a subsequent four-month course of 20 or 40 IUs of intranasal insulin or placebo given to a larger group of 104 people with aMCI or mild to moderate AD. Called SNIFF-120, this single-center study reported some preservation of cognition in younger participants and some preservation of function.
https://www.researchgate.net/publication/233403463_Intranasal_delivery_of_insulin_via_the_olfactory_nerve_pathway
It has been shown that intranasal insulin administration bypasses the blood brain barrier, delivers insulin directly into the special brain areas such as the hippocampus, and obviously improves ...
https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/bab.1917
Abstract Nasal administration is a form of systemic administration in which drugs are insufflated through the nasal cavity. Steroids, nicotine replacement, anti‐migraine drugs, and peptide drugs ar...
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