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https://www.hindawi.com/journals/jir/2019/8303648/
Intradermal immunization for vaccine delivery is an upcoming strategy showing significant advantages over conventional vaccination routes. In particular, in the last few years, intradermal vaccination has gained momentum as an alternative and more effective vaccine delivery route, both from a scientific and a commercial point of view (Table 3).Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
https://www.who.int/immunization/programmes_systems/supply_chain/optimize/Intradermal-delivery-vaccines_report_2009-Sept.pdf
Intradermal Delivery of Vaccines Executive summary The dermis and epidermis of the human skin are rich in antigen-presenting cells. It has been proposed that delivery of vaccine antigens to these tissues (i.e., intradermal delivery) rather than to muscle or subcutaneous tissue could therefore induce superior protective immune
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044245/
Mar 01, 2011 · Delivery of vaccine antigens to the dermis and/or epidermis of human skin (i.e. intradermal delivery) might be more efficient than injection into the muscle or subcutaneous tissue, thereby reducing the volumes of antigen. This is known as dose-sparing ...Author: JK Hickling, KR Jones, M Friede, D Zehrung, D Chen, D Kristensen
https://www.sciencedirect.com/science/article/pii/S0264410X08003915
Vaccine delivery into these layers is known, respectively as transdermal, intradermal and subcutaneous vaccination. Download : Download full-size image; Fig. 1. Skin anatomy. Skin thickness was measured by 20 MHz ultrasound echography in usual body sites for vaccine delivery .Author: Paul Henri Lambert, Philippe E. Laurent
https://www.ncbi.nlm.nih.gov/pubmed/30949518
Mar 04, 2019 · In this regard, recent work has been focused on vaccine delivery systems, as an alternative to injectable vaccines, to increase antigen stability and improve overall immunogenicity. In particular, novel strategies based on edible or intradermal vaccine formulations have been demonstrated to trigger both a systemic and mucosal immune response.Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
https://www.nanopass.com/technology/
Patented Technology. Hollow microneedles for intradermal injection. Intradermal delivery. Intradermal vaccine delivery has been repeatedly shown to allow significant dose sparing when compared to conventional administration methods such as intramuscular and …
https://www.westpharma.com/products/intradermal-delivery
Intradermal Delivery An easy and reliable solution for intradermal injection The ID Adapter is a novel injection guide designed for use with 1mL 1/2 inch fixed needle allergy syringes.
https://www.drugdeliverybusiness.com/inovio-touts-intradermal-delivery-of-hiv-vaccine/
Oct 26, 2018 · Inovio reported that 96% of people receiving Pennvax-GP and IL-12 via intramuscular delivery experienced a CD4 + T cell response. The same percentage of participants receiving the vaccine via intradermal administration experienced a CD4 + T cell response, despite receiving a smaller dose than those who received the vaccine intramuscularly.
https://www.sciencedirect.com/science/article/pii/S0264410X14003685
Multiple approaches are being evaluated to achieve better influenza vaccine immunogenicity and reduce the dose required for vaccination. Intradermal delivery has been proposed as a means of dose sparing in adults , , , children , and infants , as well as in the elderly .Author: Yotam Levin, Efrat Kochba, Richard Kenney
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