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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455430/
Before the discovery of insulin, type 1 DM was a uniformly mortal disease, but even with today’s plethora of insulin delivery systems, such as insulin pumps, short and long-acting insulin analogues, and transplantation of islets of Langerhans, or whole pancreas, DM …Author: Michael Hultström, Niclas Roxhed, Lina Nordquist
https://professional.diabetes.org/abstract/comparison-between-intradermal-and-subcutaneous-insulin-delivery-novel-biphasic-model
Comparison between Intradermal and Subcutaneous Insulin Delivery Via a Novel Biphasic Model of Insulin Absorption Intradermal insulin delivery Intradermal insulin delivery is an attractive alternative to subcutaneous insulin delivery due to more rapid absorption kinetics that could potentially improve glycemic control in patients with diabetes ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529466/
Intradermal insulin infusion achieves faster insulin action than subcutaneous infusion for 3-day wear. ... Intradermal delivery of insulin is a viable delivery route alternative providing reduced time for insulin absorption with less intra-subject variability and lower glycemic response.Author: Christopher James Rini, Elaine McVey, Diane Sutter, Stephen Keith, Heinz-Joerg Kurth, Leszek Nosek, ...
https://journals.sagepub.com/doi/10.1177/1932296814530060
Apr 10, 2014 · Insulin deficiency is the hallmark of diabetes mellitus (DM) type 1 and plays an important role in type 2 DM. Before the discovery of insulin, type 1 DM was a uniformly mortal disease, but even with today’s plethora of insulin delivery systems, such as insulin pumps, short and long-acting insulin analogues, and transplantation of islets of Langerhans, or whole pancreas, DM still causes to ...Author: Michael Hultström, Niclas Roxhed, Lina Nordquist
https://journals.sagepub.com/doi/pdf/10.1177/1932296814530060
Intradermal Insulin Delivery: A Promising Future for Diabetes Management Michael Hultström, MD, PhD1,2, Niclas Roxhed, PhD3, and Lina Nordquist, PhD1 Abstract The incidence of insulinopenic diabetes mellitus is constantly increasing, and in addition, approximately a third of all hyperinsulinemic diabetic patients develop insulinopenia.
https://www.sciencedirect.com/science/article/pii/S0928493118330704
3D printed microneedle arrays were fabricated using a biocompatible resin through stereolithography (SLA) for transdermal insulin delivery. Microneedles were built by polymerising consecutive layers of a photopolymeric resin. Thin layers of insulin and sugar alcohol or disaccharide carriers were formed on the needle surface by inkjet printing.Author: Sophia N. Economidou, Cristiane Patricia Pissinato Pere, Andrew Reid, Md. Jasim Uddin, James F.C. Wi...
https://professional.diabetes.org/abstract/intra-dermal-insulin-lispro-application-new-microneedle-delivery-system-led-substantially
Intra-Dermal Insulin Lispro Application with a New Microneedle Delivery System Led to a Substantially More Rapid Insulin Absorption Than Subcutaneous Injection We investigated the pharmacoki We investigated the pharmacokinetic and pharmacodynamic effects of insulin Lispro applied intra-dermally with a new microneedle delivery system.
https://www.liebertpub.com/doi/full/10.1089/dia.2016.0156
Sep 01, 2016 · 20 Norman JJ, Brown MR, Raviele NA, et al.: Faster pharmacokinetics and increased patient acceptance of intradermal insulin delivery using a single hollow microneedle in children and adolescents with type 1 diabetes. Pediatr Diabetes 2013;14:459–465. Crossref, Medline, Google ScholarAuthor: Efrat Kochba, Yotam Levin, Itamar Raz, Avivit Cahn
https://www.researchgate.net/publication/262786780_Intradermal_Insulin_Delivery_A_Promising_Future_for_Diabetes_Management
These will improve not only efficacy but in the case of intradermal delivery, adherence to insulin-based therapy -cannula insertion can be extremely painful [32] (carried out every 3 days), and ...
https://drug-dev.com/intradermal-delivery-new-technology-brings-simplicity-scalability-to-intradermal-drug-delivery/
These approved drugs will see a rapid path to commercial adoption of hollow microneedle-based injection systems. Drugs that are suitable, but not yet approved, for intradermal delivery, such as insulin, will require a combination product clinical trial before completely …
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