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https://mayoclinic.pure.elsevier.com/en/publications/intracellular-fate-of-a-targeted-delivery-system
Dec 01, 2008 · title = "Intracellular fate of a targeted delivery system", abstract = "Targeted delivery of a drug to the malignant cells should result in enhanced therapeutic efficacy with low to minimal side effects. This is a widely accepted concept, but limited in application due to lack of available technologies and process of validation.Author: Chitta Ranjan Patra, Sheng Cao, Stephanie Safgren, Resham Bhattacharya, Matthew M. Ames, Vijay Shah,...
https://www.ingentaconnect.com/content/asp/jbn/2008/00000004/00000004/art00017
Nanotechnology can play an important role in this aspect. In this article, we report the investigation on the intracellular fate of such a targeted delivery system containing gold nanoparticle (AuNP) as a delivery vehicle, gemcitabine (Gem) as a cytotoxic drug and cetuximab (C225) as a targeting agent.
https://www.researchgate.net/publication/233639236_Intracellular_Fate_of_a_Targeted_Delivery_System
Request PDF Intracellular Fate of a Targeted Delivery System Targeted delivery of a drug to the malignant cells should result in enhanced therapeutic efficacy with low to minimal side effects ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984483/
Aug 10, 2016 · Chemical modifications have also been extensively explored for targeted delivery of protein- and RNA-based drugs and may also offer valuable solutions for in vivo targeting 130, 131. However, in the absence of comprehensive comparisons of uptake, intracellular distribution, and degradation, it is difficult to assess which approach to ...Author: Shane Miersch, Sachdev S. Sidhu
https://pubs.acs.org/doi/abs/10.1021/ja503010a
May 19, 2014 · Here, we report studies aimed at determining the intracellular fate of SNAs and the trafficking events that occur inside C166 mouse endothelial cells after cellular entry. We show that SNAs traffic through the endocytic pathway into late endosomes and reside there for …Author: Xiaochen A. Wu, Chung Hang J. Choi, Chung Hang J. Choi, Chuan Zhang, Liangliang Hao, Chad A. Mirkin
https://pubs.acs.org/doi/10.1021/acs.nanolett.7b03021
Intracellular Fate of Nanoparticles with Polydopamine Surface Engineering and a Novel Strategy for Exocytosis-Inhibiting, Lysosome Impairment-Based Cancer TherapyAuthor: Li Ding, Xianbing Zhu, Yiling Wang, Bingyang Shi, Xiang Ling, Houjie Chen, Wenhao Nan, Austin Barret...
https://www.researchgate.net/publication/240910431_The_intracellular_fate_of_non-viral_DNA_carriers
Additionally, the intracellular fate of different self-assemblies has been studied by different groups. Together, these studies provide a rational basis for designing novel DNA delivery agents.Author: Marek Langner
https://www.nature.com/articles/s41467-018-03705-y
Apr 12, 2018 · Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to the plethora of successful pre-clinical studies, only 15 passively targeted nanocarriers (NCs) have been approved for clinical use and none of the actively targeted NCs have advanced past clinical trials.Author: Daniel Rosenblum, Nitin Joshi, Nitin Joshi, Wei Tao, Jeffrey M. Karp, Jeffrey M. Karp, Dan Peer
https://www.sciencedirect.com/science/article/pii/S0168365911000368
Potential targeted drug delivery systems, therefore, should be able to overcome not only extracellular barriers (long circulation time, preferential accumulation at diseased sites, selective binding to the targeted cells, etc.) but also equally important intracellular barriers (cellular internalization, endosomal escape, drug release, etc.).Author: Ru Cheng, Fang Feng, Fenghua Meng, Chao Deng, Jan Feijen, Zhiyuan Zhong
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