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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/intracellular-drug-delivery
Intracellular drug delivery for most purposes is hampered by problems related to the efficacy of delivery as well as to endocytotic processing and degradation. Numerous attempts have been made to develop an efficient intracellular drug and DNA delivery system bypassing the endocytotic pathway.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653259/
In the context of small molecular weight hydrophobic drugs at least, the results of this study warrant the following recommendations for future development of PLGA NP systems as an intracellular drug delivery system. First, leaching-out of the payload from PLGA NPs during their …Author: Peisheng Xu, Emily Gullotti, Ling Tong, Christopher B. Highley, Divya R. Errabelli, Tayyaba Hasan, J...
https://pdfs.semanticscholar.org/5f5e/f78659f8e3470c45780a8ed257bfccc16def.pdf
strategies in achieving intracellular delivery of the drug payloads. 2.1. Covalent Conjugation of Therapeutic Agents with CPP The commonly used strategy for CPP-assisted drug delivery is by covalent conjugation, either chemically or biologically, of CPPs with the therapeutic agents. In 1999, a recombinant
https://www.ncbi.nlm.nih.gov/pubmed/28736333
A nanoparticle drug carrier system has been developed to alter the cellular uptake and chemotherapeutic performance of an available chemotherapeutic drug. The system comprises of a multifunctional gold nanoparticle based drug delivery system (Au-PEG-PAMAM-DOX) as a novel platform for intracellular delivery of doxorubicin (DOX).Author: Ganesh V. Khutale, Alan Casey
https://www.intechopen.com/books/smart-drug-delivery-system/antibiotic-drug-delivery-systems-for-the-intracellular-targeting-of-bacterial-pathogens
Antibiotic Drug Delivery Systems for the Intracellular Targeting of Bacterial Pathogens. By Mariana Carmen Chifiriuc, Alina Maria Holban, Carmen Curutiu, Lia- Mara Ditu, Grigore Mihaescu, Alexandra Elena Oprea, Alexandru Mihai Grumezescu and Veronica Lazar. Submitted: March 20th 2015 Reviewed: August 24th 2015 Published: February 10th 2016Author: Mariana Carmen Chifiriuc, Alina Maria Holban, Carmen Curutiu, Lia Mara Ditu, Grigore Mihaescu, Alexa...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30115-0
May 01, 2015 · Antibodies armed with biologic drugs could greatly expand the therapeutic potential of antibody–drug conjugates for cancer therapy, broadening their application to disease targets currently limited by intracellular delivery barriers. Additional selectivity and new therapeutic approaches could be realized with intracellular protein drugs that more specifically target dysregulated pathways in ...Author: Geoffrey Y Berguig, Anthony J Convertine, Shani Frayo, Hanna B Kern, Erik Procko, Erik Procko, Debas...
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201807795
A biomechanical energy‐powered triboelectric nanogenerator (TENG)‐driven electroporation system is developed for intracellular drug delivery in vitro and in vivo. The self‐powered TENG with a silicon...Author: Zhirong Liu, Jinhui Nie, Bin Miao, Jiadong Li, Yuanbo Cui, Shu Wang, Xiaodi Zhang, Gengrui Zhao, Yon...
https://www.researchgate.net/publication/231817032_Trojan-Horse_Nanotube_On-Command_Intracellular_Drug_Delivery
A major challenge to nanomaterial-based medicine is the ability to release drugs on-command. Here, we describe an innovative drug delivery system based on carbon nanotubes (CNTs), in which ...
https://www.sciencedirect.com/topics/medicine-and-dentistry/intracellular-drug-delivery
Intracellular drug delivery for most purposes is hampered by problems related to the efficacy of delivery as well as to endocytotic processing and degradation. Numerous attempts have been made to develop an efficient intracellular drug and DNA delivery system bypassing the endocytotic pathway.
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are …
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