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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/intracellular-drug-delivery
Intracellular drug delivery for most purposes is hampered by problems related to the efficacy of delivery as well as to endocytotic processing and degradation. Numerous attempts have been made to develop an efficient intracellular drug and DNA delivery system bypassing the endocytotic pathway.
https://www.ncbi.nlm.nih.gov/pubmed/26675221
Also, better knowledge of non-classical endocytic pathways may help optimize targeted drug delivery systems for intracellular delivery. Therefore, this review focuses on mechanisms of intracellular delivery, including direct internalization and endocytosis, as well as factors such as targeting moiety, target receptor, and size, shape, and surface properties of the drug carrier that can influence uptake …Author: Carmen Garnacho
https://www.ncbi.nlm.nih.gov/pubmed/16834560
Intracellular delivery of various drugs, including DNA, and drug carriers can sharply increase the efficiency of various treatment protocols. However, the receptor-mediated endocytosis of drugs, drug carriers, and DNA results in their lysosomal delivery and significant degradation.Author: Vladimir P. Torchilin
https://www.medcraveonline.com/PPIJ/review-on-targeted-drug-delivery-against-intracellular-pathogen.html
Cellular penetration and intracellular delivery: One critical challenge in treating intracellular pathogens is to get enough drugs to reach the pathogen within an intracellular compartment. Nanoparticles may reside within acidic endolysosome compartments following endocytosis, and premature drug release within this acidic compartment may cause drug degradation and render treatment ineffective.
https://pubs.acs.org/doi/10.1021/acs.chemrev.7b00678
Abstract. Intracellular delivery is a key step in biological research and has enabled decades of biomedical discoveries. It is also becoming increasingly important in industrial and medical applications ranging from biomanufacture to cell-based therapies. Here, we review techniques for membrane disruption-based intracellular delivery from 1911...Author: Martin P. Stewart, Martin P. Stewart, Robert Langer, Klavs F. Jensen
https://www.researchgate.net/publication/287212089_Intracellular_Drug_Delivery_Mechanisms_for_Cell_Entry
Therefore, this review focuses on mechanisms of intracellular delivery, including direct internalization and endocytosis, as well as factors such as targeting moiety, target receptor, and size, shape, and surface properties of the drug carrier that can influence uptake process.Author: Carmen Garnacho
https://www.ncbi.nlm.nih.gov/pubmed/30469344
Nov 21, 2018 · Intracellular delivery is a critical step in biological discoveries and has been widely utilized in biomedical research. A variety of molecular tools have been developed for cell-based gene therapies, including FDA approved CAR-T immunotherapy, iPSC, cell reprogramming and gene editing.Author: Junfeng Shi, Yifan Ma, Jing Zhu, Yuanxin Chen, Yating Sun, Yicheng Yao, Zhaogang Yang, Jing Xie
https://www.tandfonline.com/doi/abs/10.1080/17425247.2019.1676720
Introduction: Cell penetrating peptides (CPPs) known as protein translocation domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able to cross biological membranes without clear toxicity using different mechanisms, and facilitate the intracellular delivery of a variety of bioactive cargos. CPPs could overcome some limitations of drug delivery and combat resistant strains against a …Author: Kimia Kardani, Alireza Milani, Samaneh H. Shabani, Azam Bolhassani
https://www.researchgate.net/publication/51815471_Nanoparticles_for_intracellular-targeted_drug_delivery
Although initial studies in the area of intracellular drug delivery have been performed in the delivery of DNA, there is an increasing interest in the use of other molecules to modulate cell...
https://www.nature.com/articles/s41392-017-0004-3
Mar 16, 2018 · Moreover, they can also be used for 3D cell culture and as drug delivery vehicles 108,109. Hydrogels are efficient candidates for controlled release, bioadhesive and/or targeted drug delivery as they can encapsulate biomacromolecules, including proteins and DNA, and hydrophilic or hydrophobic drugs 110.Author: Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar, Pralay Maiti
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