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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900005/
Jan 01, 2014 · This led to the concept of “seroswitch,” that is, to circumvent the antiadenovirus immunity elicited by the initial administration of an adenovirus gene transfer vector by administering an adenovirus vector comprised of a different serotype carrying the same gene, a strategy that is effective in experimental animals (Mastrangeli et al., 1996; Mack et al., 1997). However, while seroswitch will …Author: Ronald G. Crystal
https://link.springer.com/protocol/10.1007%2F978-1-59745-104-8_10
Gene Delivery by Adenoviruses. Abstract. Adenoviruses have a number advantages as gene delivery vectors, including ability to transduce a wide variety of non-dividing and dividing cells with high efficiency, relative ease of construction, and ability to be purified as high-titer viral stocks.Author: Renny T. Franceschi, Chunxi Ge
https://www.nejm.org/doi/full/10.1056/NEJM199605023341809
Adenoviruses as Gene-Delivery Vehicles. James M. Wilson, M.D., Ph.D. This article has no abstract; the first 100 words appear below. For gene therapy to realize its clinical potential, there must be efficient and safe strategies of delivering therapeutic genes to somatic cells in vivo.Author: James M. Wilson
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass. We compared the ability of adeno-associated virus (AAV), adenovirus (Ad), and lentiviral (LV) vectors to deliver genes to renal cells.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.researchgate.net/publication/5387446_Gene_Delivery_by_Adenoviruses
Adenoviruses have a number advantages as gene delivery vectors, including ability to transduce a wide variety of non-dividing and dividing cells with high efficiency, relative ease of construction,...
https://www.sciencedirect.com/science/article/pii/S2352304217300272
Among all currently available viral vectors, adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types. The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.Author: Cody S. Lee, Elliot S. Bishop, Ruyi Zhang, Ruyi Zhang, Xinyi Yu, Xinyi Yu, Evan M. Farina, Shujuan Y...
https://www.ncbi.nlm.nih.gov/pubmed/27492853
The goal of our study was to improve tumor-specific adenovirus-mediated gene delivery by selectively targeting the adenovirus binding to this radiation-inducible protein. We employed an adenoviral fiber replacement approach to conduct a study of the targeting utility of GRP78-binding peptide.Author: S. A. Kaliberov, L. N. Kaliberova, H. Yan, V. Kapoor, Dennis Hallahan
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(04)01342-5
Oct 01, 2004 · Adenoviruses were initially vectored as vehicles for gene therapy. Attempts to replace missing or faulty genes by adenoviral gene transfer were largely unsuccessful in experimental animals and human volunteers alike due to innate and adaptive immune responses induced by the adenoviral …Author: Nia Tatsis, Hildegund C.J. Ertl
https://www.intechopen.com/books/adenoviruses/adenoviral-vector-based-vaccines-and-gene-therapies-current-status-and-future-prospects
Adenoviruses are excellent vectors for delivering genes or vaccine antigens to the target host tissues and are being tested in several vaccine and gene therapy studies. Adenovirus-based vectors offer several advantages over other viral vectors such as broad range of tissue tropism, well-characterized genome…Author: Shakti Singh, Rakesh Kumar, Babita Agrawal
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