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https://www.sciencedirect.com/science/article/pii/S0169409X11001414
The intestinal lymphatic drug transport exhibits a number of advantages over the oral absorption via the portal blood. For instance, drugs that are transported via the intestinal lymphatic system enter the systemic circulation without first passing through the liver.Author: Jaime A. Yáñez, Stephen W.J. Wang, Ian W. Knemeyer, Mark A. Wirth, Kevin B. Alton
https://www.sciencedirect.com/science/article/abs/pii/S0169409X11001414
Intestinal lymphatic transport has been shown to be an absorptive pathway following oral administration of lipids and an increasing number of lipophilic drugs, which once absorbed, diffuse across the intestinal enterocyte and while in transit associate with secretable enterocyte lipoproteins.Author: Jaime A. Yáñez, Stephen W.J. Wang, Ian W. Knemeyer, Mark A. Wirth, Kevin B. Alton
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120490/
Nov 23, 2016 · Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This ...Author: Hyeji Ahn, Ji-Ho Park
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732201/
Jul 26, 2013 · In the intestinal permeability model, Caco-2 cells are used to evaluate intracellular lipoprotein-lipid assembly and to examine the effect of lipids and lipidic excipients on incorporation of drug with lipoproteins in lymphatic transport.88,105–107 In one in vitro model, Gershkovich and Hoffman described a correlation between the degree of ex ...Author: Arshad Ali Khan, Jahanzeb Mudassir, Noratiqah Mohtar, Yusrida Darwis
https://www.researchgate.net/publication/51235042_Intestinal_lymphatic_transport_for_drug_delivery
Intestinal lymphatic transport has been shown to be an absorptive pathway following oral administration of lipids and an increasing number of lipophilic drugs, which once absorbed, diffuse across ...
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-016-0083-1
Nov 23, 2016 · Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport ...Author: Hyeji Ahn, Ji-Ho Park
https://www.researchgate.net/publication/310751449_Liposomal_delivery_systems_for_intestinal_lymphatic_drug_transport
The lymphatic system that extends throughout the whole body is one of useful targets for efficient drug delivery. The intestinal lymphatic drug delivery has been actively studied to date because ...
https://pubs.acs.org/doi/abs/10.1021/acsnano.8b04315
Herein, we describe a simple and promising nanoparticle oral delivery phenomenon and propose pathways for oral nanoparticle absorption from the gastrointestinal tract (GIT), combining apical sodium-dependent bile acid transporter-mediated cellular uptake and chylomicron transport pathways. This strategy is proven to employ bile-acid-conjugated, solid fluorescent probe nanoparticles (100 nm ...Author: Kyoung Sub Kim, Kenichi Suzuki, Hana Cho, Yu Seok Youn, Yu Seok Youn, You Han Bae
https://www.deepdyve.com/lp/elsevier/intestinal-lymphatic-transport-for-drug-delivery-xp0T7N0F6Z
Sep 10, 2011 · Intestinal lymphatic transport has been shown to be an absorptive pathway following oral administration of lipids and an increasing number of lipophilic drugs, which once absorbed, diffuse across the intestinal enterocyte and while in transit associate with secretable enterocyte lipoproteins. The chylomicron-associated drug is then secreted from the enterocyte into the lymphatic circulation ...
https://pharmawiki.in/ppt-lymphatic-transport-of-drugs/
Jan 22, 2014 · Contents of the powerpoint on Lymphatic transport of drugs include: CONTENTS Introduction Physiology of lymphatic system Intestinal lymphatic drug transport Promotion of intestinal lymphatic drug transport Prodrug approaches for enhanced lymphatic delivery Formulation approaches for enhanced intestinal lymphatic transport Conclusion References Lymphatic system Lymphatic …
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