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https://www.sciencedirect.com/science/article/pii/S1471489217301194
Intestinal patch-based devices. Intestinal patches are inspired by transdermal patches, which in spite of similar conceptual design, operate in very different physiological environments [].Transdermal patches are developed for drug delivery through the skin, are larger in size (inches) and include an adhesive layer to stick to skin, a drug reservoir and a water impermeable backing layer.Author: Amrita Banerjee, Samir Mitragotri, Samir Mitragotri
https://www.ncbi.nlm.nih.gov/pubmed/28850875
Intestinal patch based devices prevent drug degradation in the gastrointestinal tract, facilitate their intestinal absorption through forming a localized drug depot at the delivery site and provide unidirectional, controlled drug release while preventing luminal drug loss. Consequently, intestinal patch-based devices are being developed for ...Author: Amrita Banerjee, Samir Mitragotri, Samir Mitragotri
https://link.springer.com/article/10.1023/A:1015118923204
Oral route offers an attractive mode of drug administration, although its applications are limited by poor stability of peptides and proteins in the gastrointestinal tract. In this article, we report a novel method based on intestinal patches for oral drug delivery.Author: Zancong Shen, Samir Mitragotri
https://www.researchgate.net/publication/11339903_Intestinal_Patches_for_Oral_Drug_Delivery
Mucoadhesive intestinal patches have also been investigated for oral delivery of conventional drug molecules [5]. Bioadhesive polymers can be used to improve the oral absorption of peptide drugs. ...
https://www.ncbi.nlm.nih.gov/pubmed/12033369
PURPOSE: Oral route offers an attractive mode of drug administration, although its applications are limited by poor stability of peptides and proteins in the gastrointestinal tract. In this article, we report a novel method based on intestinal patches for oral drug delivery.Author: Zancong Shen, Samir Mitragotri
https://www.researchgate.net/publication/319357207_Intestinal_patch_systems_for_oral_drug_delivery
The oral drug delivery is a dynamic research field despite the numerous challenges limiting their effective delivery, such as enzyme degradation, hydrolysis and low permeability of intestinal ...
https://www.sciencedirect.com/science/article/pii/S1359644605034896
Jul 01, 2005 · A bilayered intestinal patch was designed for the oral delivery of insulin . These patches were fabricated using a mucoadhesive matrix of Carbopol®, pectin and sodium carboxymethylcellulose and loaded with bovine insulin (0.25–2.50 U/mg) as a model drug.Author: Sarah L. Tao, Tejal A. Desai
http://www.authorstream.com/Presentation/chetanmatholiya-1800264-small-intestine-drug-delivery-system/
May 05, 2013 · Recent Approaches 1 ) Intestinal Targeting using Enteric Coated HPMC capsules: In vitro and in vivo behaviour of HPMC capsules coated investigated with Eudragit L30D-55 - to achieve drug targeting to the upper small bowel with Eudragit FS30D - to provide for colonic delivery Using acetaminophen as model drug , HPMC units coated with Eudragit ...
https://www.nature.com/articles/s41591-019-0606-0
Oct 07, 2019 · A novel oral capsule can deploy microneedle patches that release drugs into the intestinal wall for uptake into the bloodstream as shown in animal studies, thereby avoiding injections.Author: Mark R. Prausnitz, Yasmine Gomaa, Yasmine Gomaa, Wei Li
https://www.deepdyve.com/lp/springer-journals/intestinal-patches-for-oral-drug-delivery-CYBd5KdmUJ
Oct 10, 2004 · Intestinal Patches for Oral Drug Delivery Intestinal Patches for Oral Drug Delivery Shen, Zancong; Mitragotri, Samir 2004-10-10 00:00:00 Purpose. Oral route offers an attractive mode of drug administration, although its applications are limited by poor stability of peptides and proteins in the gastrointestinal tract.
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