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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207587/
Oct 24, 2018 · Strategies for Intracellular Targeting of Antibodies, Their Mimics, and Derivatives: Summary of the Limitations and Prospects. Targeted intracellular delivery of antibodies can be aimed at the antigens localized in various intracellular compartments, …Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229664/
Jan 30, 2012 · EGFR serves as an important therapeutic target because of its over-expression in many cancers. In this study, we investigated a peptide-based therapy aimed at blocking intracellular protein-protein interactions during EGFR signaling and evaluated a targetable lipid carrier system that can deliver peptides to intracellular targets in human cancer cells.Author: Sang Kyoon Kim, Leaf Huang
https://www.frontiersin.org/articles/10.3389/fphar.2018.01208/full
Oct 24, 2018 · Strategies for Intracellular Targeting of Antibodies, Their Mimics, and Derivatives: Summary of the Limitations and Prospects. Targeted intracellular delivery of antibodies can be aimed at the antigens localized in various intracellular compartments, …Author: Tatiana A. Slastnikova, A. V. Ulasov, A. A. Rosenkranz, A. A. Rosenkranz, A. S. Sobolev, A. S. Sobol...
https://www.researchgate.net/publication/328484032_Targeted_Intracellular_Delivery_of_Antibodies_The_State_of_the_Art
intracellular targeting of antibodies via protein-transduction domains or their mimics, liposomes, polymer vesicles, and viral envelopes, are reviewed in this article. The pitfalls,
https://www.nature.com/articles/ncomms15090
May 10, 2017 · Oncogenic RAS mutants are key anti-cancer targets as KRas mutations are very frequent in human cancers. Here, the authors engineer a cytosol-penetrating anti …Author: Seung-Min Shin, Dong-Ki Choi, Keunok Jung, Jeomil Bae, Ji-sun Kim, Seong-wook Park, Ki-Hoon Song, Yo...
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01001/full
Aug 18, 2017 · Monoclonal antibodies are among the most clinically effective drugs used to treat cancer. However, their target repertoire is limited as there are relatively few tumor-specific or tumor-associated cell surface or soluble antigens. Intracellular molecules represent nearly half of the human proteome and provide an untapped reservoir of potential therapeutic targets. Antibodies have been ...Author: Iva Trenevska, Demin Li, Alison H. Banham
https://www.sciencedirect.com/science/article/pii/S0168365911005827
EGFR serves as an important therapeutic target because of its over-expression in many cancers. In this study, we investigated a peptide-based therapy aimed at blocking intracellular protein–protein interactions during EGFR signaling and evaluated a targetable lipid carrier system that can deliver peptides to intracellular targets in human cancer cells.Author: Sang Kyoon Kim, Leaf Huang
https://link.springer.com/article/10.1007/s00066-014-0743-9
Aug 27, 2014 · The epidermal growth factor receptors, EGFR (HER1) and HER2, have proven prognostic relevance in a variety of human malignancies and both are functionally involved in the molecular pathogenesis of malignant gliomas. We selectively inhibited EGFR and HER2 in glioblastoma cell lines via EGFR- and HER2-specific siRNAs and through the binding of the therapeutic antibodies …Author: Henri Wichmann, Antje Güttler, Matthias Bache, Helge Taubert, Swetlana Rot, Jacqueline Kessler, Alex...
https://academic.oup.com/nar/article/47/10/e55/5365579
Feb 27, 2019 · These observations are in line with previous findings that (i) noncovalent hapten-coupled payloads separate from targeting antibodies after internalization and become routed independently from the antibody (64,65) and (ii) that most antibodies bind to cells and internalize in an effective manner but by themselves have very low propensity to ...Author: Tobias Killian, Annette Buntz, Teresa Herlet, Heike Seul, Olaf Mundigl, Gernot Längst, Ulrich Brinkm...
https://www.researchgate.net/publication/276543789_Enhanced_Therapeutic_Epidermal_Growth_Factor_Receptor_EGFR_Antibody_Delivery_via_Pulsed_Ultrasound_with_Targeting_Microbubbles_for_Glioma_Treatment
This study evaluates the use of epidermal growth factor receptor (EGFR)-targeting MBs after pUS treatment to enhance the effects of therapeutic-EGFR antibody delivery to glioma tumor cells in mice.
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