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https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201901489
Cell‐specific drug delivery remains a major unmet challenge for cancer nanomedicines. Here, light‐triggered, cell‐specific delivery of liposome‐encapsulated doxorubicin to xenograft human cancer cells in live zebrafish embryos is demonstrated.Author: Li Kong, Quanchi Chen, Frederick Campbell, Ewa Snaar‐Jagalska, Alexander Kros
https://www.sciencedirect.com/science/article/pii/S0168365919305061
Limitations and special considerations of zebrafish model are also discussed. Overall, zebrafish is expected to serve as a high-throughput screening platform for nanotoxicity and drug delivery assessment, which may instruct the design of safe nanomaterials and more effective nanomedicines.Author: Hao-Ran Jia, Ya-Xuan Zhu, Qiu-Yi Duan, Zhan Chen, Fu-Gen Wu
https://www.ncbi.nlm.nih.gov/pubmed/19275547
Presently, the research using zebrafish is expanding into other areas such as pharmacology, clinical research as a diseases model and interestingly in drug discovery. The use of zebrafish in pharmaceutical research and discovery and drug development is mainly screening of lead compounds, target identification, target validation, morpholino ...Author: Chiranjib Chakraborty, Chi Hsin Hsu, Zhi Hong Wen, Chang Shing Lin, Govindasamy Agoramoorthy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515116/
Apr 17, 2019 · Zebrafish have been used effectively for drug screening . The advantages of utilizing zebrafish as an animal model are as follows: lower maintenance costs, shorter periods of testing, easily controlled experimental conditions, and most importantly, the genetic similarity between zebrafish and humans (approximately 70%) .Author: Khaled Benchoula, Alfi Khatib, Fairuz M. C. Quzwain, Che Anuar Che Mohamad, Wan Mohd Azizi Wan Sulai...
https://www.nature.com/articles/nrd4627
Sep 11, 2015 · The zebrafish, a well-established model organism in basic biomedical research, has also become tractable for numerous applications in drug discovery, from phenotypic screens to testing for ...Author: Calum A. MacRae, Randall T. Peterson
https://www.researchgate.net/publication/259339384_Zebrafish_An_in_vivo_model_for_the_study_of_liposome_mediated_drug_delivery
Conclusions: These preliminary assessments suggest that zebrafish can be used as a good in- vivo model for the study of liposome mediated drug delivery, however further investigations are required ...
https://www.researchgate.net/publication/263295164_Nanoparticles_as_Drug_Delivery_System_against_Tuberculosis_in_Zebrafish_Embryos_Direct_Visualization_and_Treatment
Jun 19, 2014 · Nanoparticles as Drug Delivery System against Tuberculosis in Zebrafish Embryos: Direct Visualization and Treatment. June 2014; ACS Nano 8(7) ...
https://www.sciencedirect.com/science/article/pii/S0168365917307903
Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo ... (e.g. 37 °C) can be used to extend the zebrafish model to temperature-sensitive drug delivery systems. ... this approach has the possibility to address an unmet pre-clinical need in the field of drug delivery and ...Author: Sandro Sieber, Philip Grossen, Pascal Detampel, Salome Siegfried, Dominik Witzigmann, Jörg Huwyler
https://www.liebertpub.com/doi/full/10.1089/zeb.2018.1681
Mar 27, 2019 · As an example, injecting liposomal clodronate into animal models, including zebrafish, is routinely used to deliver toxic levels of clodronate specifically to macrophages for targeted cell ablation. Here we show that liposomes can also target the delivery of drugs to zebrafish macrophages to selectively manipulate their function.Author: Zimei Wu, Ben Koh, Lisa M. Lawrence, Manju Kanamala, Bregina Pool, Darren Svirskis, Nicola Dalbeth, ...
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