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https://www.ncbi.nlm.nih.gov/pubmed/26675221
Intracellular Drug Delivery: Mechanisms for Cell Entry. Garnacho C(1). Author information: (1)Department of Normal and Pathological Histology and Cytology, School of Medicine, University of Seville, Avenida Sanchez Pizjuan s/n, 41009 Sevilla, Spain. [email protected]: Carmen Garnacho
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/intracellular-drug-delivery
Intracellular drug delivery for most purposes is hampered by problems related to the efficacy of delivery as well as to endocytotic processing and degradation. Numerous attempts have been made to develop an efficient intracellular drug and DNA delivery system bypassing the endocytotic pathway.
https://www.ncbi.nlm.nih.gov/pubmed/16834560
Intracellular delivery of various drugs, including DNA, and drug carriers can sharply increase the efficiency of various treatment protocols. However, the receptor-mediated endocytosis of drugs, drug carriers, and DNA results in their lysosomal delivery and significant degradation.Author: Vladimir P. Torchilin
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/anie.200250653
Drug smuggling: Micelles made up of block copolymers and the anticancer drug adriamycin (ADR), which is linked to the polymer by a pH‐sensitive linker, have been prepared (see picture).Treatment of cancer cells with the micelles shows that the micelles are transported into the cell by endocytosis, thus bypassing the cell‐membrane transporters.Author: Younsoo Bae, Shigeto Fukushima, Atsushi Harada, Kazunori Kataoka
https://pdfs.semanticscholar.org/5f5e/f78659f8e3470c45780a8ed257bfccc16def.pdf
strategies in achieving intracellular delivery of the drug payloads. 2.1. Covalent Conjugation of Therapeutic Agents with CPP The commonly used strategy for CPP-assisted drug delivery is by covalent conjugation, either chemically or biologically, of CPPs with the therapeutic agents. In 1999, a recombinant
https://www.sciencedirect.com/science/article/pii/S0168365918304218
Sep 28, 2018 · In summary, a lipid raft-responsive and light-controllable polymeric drug Chol−PEG−PpIX was rationally fabricated and conveniently assembled onto liposomes via in situ membrane anchoring for safe and efficient intracellular delivery of photosensitizers.Author: Hao-Ran Jia, Ya-Xuan Zhu, Ke-Fei Xu, Xiaoyang Liu, Fu-Gen Wu
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201807795
Self‐Powered Intracellular Drug Delivery by a Biomechanical Energy‐Driven Triboelectric Nanogenerator. Zhirong Liu. Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083 P. R. China.Author: Zhirong Liu, Jinhui Nie, Bin Miao, Jiadong Li, Yuanbo Cui, Shu Wang, Xiaodi Zhang, Gengrui Zhao, Yon...
https://www.researchgate.net/publication/287212089_Intracellular_Drug_Delivery_Mechanisms_for_Cell_Entry
The mechanisms employed in cell-based micromotor applications can be improved further according to knowledge from intracellular drug delivery studies, that point out that size, shape and surface ...Author: Carmen Garnacho
https://link.springer.com/article/10.1007/s40820-019-0310-0
Sep 25, 2019 · Nanosized cytotoxic drug could combat against the autophagy induced by the drug. The drug nanorods enabled efficient intracellular delivery of the nucleic acid and the resultant autophagy inhibition in vitro and in vivo, which in turn sensitized the cancer cells to the anti-tumor nanorods.Author: Xiaofei Xin, Xiaoqing Du, Qingqing Xiao, Helena S. Azevedo, Wei He, Lifang Yin
https://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b00744
Fabrication of pH-Responsive Nanoparticles with an AIE Feature for Imaging Intracellular Drug Delivery. Xing Wang † Yanyu Yang † ‡ Yaping Zhuang † ‡ Peiyuan Gao † ‡ Fei Yang † ‡ Hong Shen † Hongxia Guo † ‡ Decheng Wu * † ‡Author: Xing Wang, Yanyu Yang, Yaping Zhuang, Peiyuan Gao, Fei Yang, Hong Shen, Hongxia Guo, Decheng Wu
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