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https://www.cell.com/cell/fulltext/S0092-8674(15)00315-3
Apr 23, 2015 · Modulation of protein function is used to intervene in cellular processes but is often done indirectly by means of introducing DNA or mRNA encoding the effector protein. Thus far, direct intracellular delivery of proteins has remained challenging.Author: Diego S. D’Astolfo, Romina J. Pagliero, Anita Pras, Wouter R. Karthaus, Hans Clevers, Vikram Prasad,...
https://pubs.acs.org/doi/10.1021/acs.accounts.8b00493
ConspectusThe use of protein to precisely manipulate cell signaling is an effective approach for controlling cell fate and developing precision medicine. More recently, programmable nucleases, such as CRISPR/Cas9, have shown extremely high potency for editing genetic flow of mammalian cells, and for treating genetic disorders. The therapeutic potential of proteins with an intracellular target ...Author: Jin Chang, Xianghan Chen, Xianghan Chen, Zachary Glass, Feng Gao, Lanqun Mao, Ming Wang, Qiaobing Xu
https://www.sciencedirect.com/science/article/pii/S1740674909000043
Because many protein and peptide drugs have their therapeutic targets inside cells, there is also an important task to bring these drugs into target cells without subjecting them to the lysosomal degradation. This review describes current approaches to the intracellular delivery of protein and peptide drugs.Author: Vladimir Torchilin
https://www.ncbi.nlm.nih.gov/pubmed/28338410
Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a ...Author: Moumita Ray, Yi-Wei Lee, Federica Scaletti, Ruijin Yu, Ruijin Yu, Vincent M Rotello
https://www.sciencedirect.com/science/article/pii/S0958166917302185
Protein therapeutics that function inside of cells: an emerging class of therapeutics. Overview of the four major applications of intracellular protein delivery: vaccine development, transcription factor therapy, gene editing and cancer therapy. Schematic diagram describing intracellular protein delivery.Author: Yumiao Zhang, Joachim Justad Røise, Kunwoo Lee, Jie Li, Niren Murthy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783992/
Feb 22, 2016 · 3. Cell-Penetrating Peptides (CPPs) Facilitate Intracellular Protein Therapy. The availability of CPPs to deliver therapeutically active cargo to the intracellular environment provides a novel platform for the development of medical treatments using molecules that would otherwise be ineffective without cellular entry.Author: Ana Dinca, Wei Ming Chien, Michael T. Chin
https://www.nature.com/articles/ncomms12277
Jul 22, 2016 · Intracellular proteins have been identified for their potential as biopharmaceutical drugs; however, many of the challenges associated with intracellular protein delivery have yet to be solved 1.Author: Nambin Yim, Seung Wook Ryu, Kyungsun Choi, Kwang Ryeol Lee, Seunghee Lee, Hojun Choi, Jeongjin Kim, ...
https://onlinelibrary.wiley.com/doi/10.1002/anie.201901699
Mitochondria‐Targeting, Intracellular Delivery of Native Proteins Using Biodegradable Silica Nanoparticles. Dr. Peiyan Yuan. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Singapore. School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510275 China.Author: Peiyan Yuan, Peiyan Yuan, Xin Mao, Xiaofeng Wu, Si Si Liew, Lin Li, Shao Q. Yao
https://pubs.rsc.org/en/content/articlelanding/2011/cs/c0cs00227e
Proteins play a crucial role in life, taking part in all vital processes in the body. In the past decade, there was increasing interest in delivering active forms of proteins to specific cells and organs. Intracellular protein delivery holds enormous promise for biological and medical applications,Author: Zhen Gu, Anuradha Biswas, Muxun Zhao, Yi Tang
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201711651
Intracellular delivery of therapeutic proteins is highly challenging and in most cases requires chemical or genetic modifications. Herein, two complementary approaches for endocytosis‐independent delivery of proteins to live mammalian cells are reported. By using either a “glycan” tag naturally derived from glycosylated proteins or a ...Author: Linghui Qian, Jiaqi Fu, Peiyan Yuan, Shubo Du, Wei Huang, Lin Li, Shao Q. Yao
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