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https://www.sciencedirect.com/science/article/pii/S1740674909000043
Because many protein and peptide drugs have their therapeutic targets inside cells, there is also an important task to bring these drugs into target cells without subjecting them to the lysosomal degradation. This review describes current approaches to the intracellular delivery of protein and peptide drugs.Author: Vladimir Torchilin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783992/
Feb 22, 2016 · 3. Cell-Penetrating Peptides (CPPs) Facilitate Intracellular Protein Therapy. The availability of CPPs to deliver therapeutically active cargo to the intracellular environment provides a novel platform for the development of medical treatments using molecules that would otherwise be ineffective without cellular entry.Author: Ana Dinca, Wei Ming Chien, Michael T. Chin
https://www.ncbi.nlm.nih.gov/pubmed/24981097
Intracellular delivery of protein and peptide therapeutics. Torchilin V(1). Author information: (1)Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA. Electronic address:[email protected]: Vladimir Torchilin
https://www.researchgate.net/publication/247280351_Intracellular_delivery_of_protein_and_peptide_therapeutics
Intracellular delivery of protein and peptide therapeutics Article in Drug Discovery Today Technologies 5(2) · September 2008 with 76 Reads How we measure 'reads'
http://www.ldbiopharma.com/document/technical/intracellular.pdf
Intracellular delivery of protein and peptide therapeutics Vladimir Torchilin Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA Many proteins and peptides are used as highly specific andeffectivetherapeuticagents.Theiruseis ...
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154081
In conclusion, our designed fusion peptide system can deliver proteins with a wide range of molecular weights (27 to 150 kDa) into the cells of intact A. thaliana without interfering with the organelle-targeting peptide conjugated to the protein. We expect that this efficient protein delivery system will be a powerful tool in plant biotechnology.Author: Kiaw Kiaw Ng, Yoko Motoda, Satoru Watanabe, Ahmad Sofiman Othman, Takanori Kigawa, Takanori Kigawa, ...
https://www.researchgate.net/publication/295685173_Intracellular_Delivery_of_Proteins_with_Cell-Penetrating_Peptides_for_Therapeutic_Uses_in_Human_Disease
Intracellular Delivery of Proteins with Cell-Penetrating Peptides for Therapeutic Uses in Human Disease ... protein cargoes covalently attached via a peptide bond or as non-covalent protein ...
https://www.nature.com/articles/srep32301
Sep 08, 2016 · EEDs address the critical rate-limiting step of endosomal escape in delivery of macromolecular biologic peptide, protein and siRNA therapeutics into …Author: Peter Lönn, Apollo D. Kacsinta, Xian-Shu Cui, Alexander S. Hamil, Manuel Kaulich, Khirud Gogoi, Stev...
https://www.nature.com/articles/s41598-018-30790-2
Aug 22, 2018 · The potency of each conjugate guided optimization, and conjugates were assessed in functional assays where readout is dependent on cytosolic delivery …Author: Katrin Hoffmann, Nadia Milech, Suzy M. Juraja, Paula T. Cunningham, Shane R. Stone, Richard W. Franc...
https://onlinelibrary.wiley.com/doi/10.1002/anie.201914970
Dec 21, 2019 · Cytosolic protein delivery is a prerequisite for the development of protein therapeutics that act on intracellular targets. Proteins are generally membrane‐impermeable and thus need a carrier such as a polymer to facilitate their internalization.Author: Lanfang Ren, Jia Lv, Hui Wang, Yiyun Cheng, Yiyun Cheng
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