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https://www.aao.org/annual-meeting-video/intraocular-drug-delivery-systems
Dr. Jonathan Myers discusses sustained-release drug delivery, which has the potential to eliminate compliance problems. Additionally, intraocular delivery might reduce topical side effects and allow much lower total dosages of medication.
https://www.amazon.com/Intraocular-Drug-Delivery-Glenn-Jaffe/dp/0367453819
Intraocular Drug Delivery 1st Edition by Glenn J. Jaffe (Editor), Paul Ashton (Editor), P. Andrew Pearson (Editor) & 0 moreAuthor: Glenn J. Jaffe
https://www.sciencedirect.com/topics/medicine-and-dentistry/intraocular-drug-administration
Ocular drug delivery is one of the most challenging administration routes, due to the eye’s unique anatomy and physiology. In general, drug absorption into the eye is limited and generally, less than 10% of the administered drug reaches the posterior segment of the eye. ... Intraocular injection would appear to introduce labeled precursors by ...
http://www.mavery.com/academic/Intraocular_DDS.pdf
What is an intraocular drug delivery system? An intraocular drug deliver system (DDS) refers to a device that is surgically implanted into your eye and then ideally would constantly releases drugs for a set time. This includes both biodegradable and non-biodegradable devices, and the development of
https://link.springer.com/chapter/10.1007/978-3-319-29346-2_18
Nov 13, 2016 · Posterior segment ocular (vitreoretinal) disorders are the foremost contributors to visual impairment and, ultimately, blindness. This is placing an increasing demand on the pharmaceutical scientist to formulate effective ophthalmic drug delivery systems.Author: Viness Pillay, Yahya E. Choonara, Lisa C. du Toit
https://www.sciencedirect.com/science/article/pii/S0142961220302076
Single topical instillation of the pilocarpine-loaded dual-functional therapeutic nanocarriers with optimized delivery performance onto experimentally glaucomatous eyes can effectively mitigate disease progression for 7 days while that employing the traditional commercial eye drops only provides a moderate treatment efficacy for 4 h, possibly due to improved intraocular drug delivery (~250-fold …Author: Li-Jyuan Luo, Duc Dung Nguyen, Jui-Yang Lai
https://www.msdvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-eye/routes-of-administration-for-ocular-medications
The three primary methods of delivery of ocular medications to the eye are topical, local ocular (ie, subconjunctival, intravitreal, retrobulbar, intracameral), and systemic. The most appropriate method of administration depends on the area of the eye to be medicated.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · MICRONEEDLE-, ULTRASOUND-, AND IONTOPHORESIS-BASED OCULAR DRUG DELIVERY SYSTEMS. All these delivery systems are noninvasive methods designed to deliver drugs to intraocular regions, mainly for the treatment of posterior segment diseases. Researchers have developed drug-coated microneedles with a length of 500 to 750 µm.Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The transscleral drug delivery with periocular administration route is evolved as an alternative mode of drug delivery to the posterior ocular tissues. Although transscleral delivery is comparatively easy, less invasive and patient compliant, drug permeation is compromised by ocular …Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.ijpbs.com/ijpbsadmin/upload/ijpbs_50c8546501de1.pdf
The purpose of this review is to provide an update on the current knowledge within this field of ocular drug delivery. Drug delivery to eye has always been a daunting task in the field of pharmaceutical research due to unique anatomy and physiology of the eye. One of the major problems encountered by conventional ocular dosage
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