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https://www.cell.com/cell/fulltext/S0092-8674(15)00315-3
Apr 23, 2015 · Modulation of protein function is used to intervene in cellular processes but is often done indirectly by means of introducing DNA or mRNA encoding the effector protein. Thus far, direct intracellular delivery of proteins has remained challenging.Author: Diego S. D’Astolfo, Romina J. Pagliero, Anita Pras, Wouter R. Karthaus, Hans Clevers, Vikram Prasad,...
https://www.ncbi.nlm.nih.gov/pubmed/28338410
Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a critical issue.Author: Moumita Ray, Yi-Wei Lee, Federica Scaletti, Ruijin Yu, Ruijin Yu, Vincent M Rotello
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783992/
Feb 22, 2016 · Intracellular delivery is crucial for many therapeutic molecules with targets inside the cell; however, the ability to get large molecules across the plasma membrane poses great challenges. Owing to reduced bioavailability in vivo, many promising candidates are not developed to …Author: Ana Dinca, Wei Ming Chien, Michael T. Chin
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201711651
Intracellular delivery of therapeutic proteins is highly challenging and in most cases requires chemical or genetic modifications. Herein, two complementary approaches for endocytosis‐independent delivery of proteins to live mammalian cells are reported.Author: Linghui Qian, Jiaqi Fu, Peiyan Yuan, Shubo Du, Wei Huang, Lin Li, Shao Q. Yao
http://www.jbc.org/content/276/37/35103.long
Sep 14, 2001 · The ability to directly inhibit or initiate other targeted intracellular functions specifically in live cells by the delivery of antibodies, recombinant proteins, or peptides will be of tremendous benefit in all aspects of cellular biology and functional genomics.Author: Olivier Zelphati
https://www.sciencedirect.com/science/article/pii/S1740674909000043
Intracellular delivery of proteins by cell-penetrating peptides (CPP) A novel approach to deliver various molecules and nanoparticles involves their modification with cell-penetrating proteins or peptides (CPPs), that is, proteins and peptides that can translocate through the cellular membranes, thereby enhancing the delivery of CPP-modified molecules inside the cell.Author: Vladimir Torchilin
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