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https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.7b02664
Intracellular delivery of mRNA holds great potential for vaccine1−3 and therapeutic4 discovery and development. Despite increasing recognition of the utility of lipid-based nanoparticles (LNPs) for intracellular delivery of mRNA, particle engineering is hindered by insufficient understanding of endosomal escape, which is believed to be a main limiter of cytosolic availability and activity of ...Author: Siddharth Patel, N. Ashwanikumar, Emily Robinson, Allison DuRoss, Conroy Sun, Kerry E. Murphy-Benena...
https://www.nature.com/articles/s41467-020-14527-2
Feb 20, 2020 · Endosomal sequestration of lipid-based nanoparticles is a barrier to delivery of nucleic acids. Here the authors test an array of cholesterol variants and perform in-depth investigation of ...Author: Siddharth Patel, N. Ashwanikumar, Ema Robinson, Yan Xia, Cosmin Mihai, Joseph P. Griffith, Shangguo ...
https://pubs.acs.org/doi/10.1021/jacs.8b12705
Intracellular protein delivery holds enormous promise for biol. and medical applications, including cancer therapy, vaccination, regenerative medicine, treatment for loss-of-function genetic diseases and imaging. This tutorial review surveys recent developments in intracellular protein …Author: Shunzhi Wang, Yijing Chen, Shuya Wang, Peng Li, Chad A. Mirkin, Omar K. Farha
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825215/
Nov 01, 2019 · Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small molecules. Most peptides and biologics are fused with cationic uptake moieties or formulated into nanoparticles to facilitate delivery, but these systems typically lack potency due to low uptake and/or entrapment and degradation in endolysosomal compartments.Author: Brian C. Evans, R. Brock Fletcher, Kameron V. Kilchrist, Eric A. Dailing, Alvin J. Mukalel, Juan M. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653259/
INTRODUCTION. Polymeric nanoparticles (NPs) have been widely explored for drug delivery. Advantages of NP systems are the small size, which makes them compatible with various administration routes including intravenous injection, and the relatively high drug encapsulation capacity (as compared to drug-polymer conjugates).Author: Peisheng Xu, Emily Gullotti, Ling Tong, Christopher B. Highley, Divya R. Errabelli, Tayyaba Hasan, J...
https://onlinelibrary.wiley.com/doi/10.1002/anie.201901699
Methods for the delivery of small‐molecule drugs to the mitochondria are available, but these are not suitable for macromolecules, such as proteins. Herein, we report the delivery of native proteins and antibodies to the mitochondria using biodegradable silica nanoparticles (BS–NPs).Author: Peiyan Yuan, Peiyan Yuan, Xin Mao, Xiaofeng Wu, Si Si Liew, Lin Li, Shao Q. Yao
https://pubs.rsc.org/en/content/articlelanding/2019/bm/c8bm00637g
Here we report a combinatorial library of disulfide bond-containing cationic lipidoid nanoparticles (LNPs) as carrier systems for intracellular Cas9/sgRNA delivery and subsequent genome editing. Nanoparticles with high efficacies of targeted gene knockout as well as relatively low cytotoxicities have been identified through in vitro screening.Author: Yamin Li, Justin Bolinger, Yingjie Yu, Zachary Glass, Nicola Shi, Liu Yang, Ming Wang, Qiaobing Xu
https://www.sciencedirect.com/science/article/pii/S1359644617302234
The intracellular delivery of nanomaterials and drugs has been attracting increasing research interest, mainly because of their important effects and functions in several organelles. Targeting specific organelles can help treat or decrease the symptoms of diabetes, cancer, …Author: Cláudia Azevedo, Maria Helena Macedo, Bruno Sarmento
https://www.nature.com/articles/s41467-019-12906-y
Nov 01, 2019 · In addition to peptides, we demonstrate that PPAA can be extrapolated as an intracellular delivery reagent for other, larger cationized biologics (Figs. 4e–g, 5), and cationic nanoparticles ...Author: Brian C. Evans, R. Brock Fletcher, Kameron V. Kilchrist, Eric A. Dailing, Alvin J. Mukalel, Juan M. ...
https://www.sciencedirect.com/science/article/pii/S0022354915305633
The results presented here illustrate the feasibility of producing protein nanoparticles for intracellular delivery of therapeutic enzymes. Particle size can be tuned by adjusting a variety of parameters, including NaCl and imidazole concentration, type of cross-linker and cross-linking time.Author: Lina Herrera Estrada, Stanley Chu, Julie A. Champion
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