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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346638/
Delivery of antituberculosis drugs by nanoparticles offers potential advantages over free drug, including the potential to target specifically the tissues and cells that are infected by Mycobacterium tuberculosis, thereby simultaneously increasing therapeutic efficacy and decreasing systemic toxicity, and the capacity for prolonged release of drug, thereby allowing less-frequent dosing.Author: Daniel L. Clemens, Bai-Yu Lee, Min Xue, Courtney R. Thomas, Huan Meng, Daniel Ferris, Andre E. Nel, ...
https://www.sciencedirect.com/science/article/pii/S0168365915302662
3. Macrophages in drug delivery 3.1. Macrophages as a target for drug delivery. Macrophages have long been an important target for drug delivery. For example, antibacterial agents are delivered to macrophages for the treatment of intracellular infections, such …Author: Yihua Pei, Yoon Yeo
https://link.springer.com/chapter/10.1007%2F3-540-36488-9_6
Jun 30, 2003 · Minimization of such adverse reactions might be feasible through drug delivery modalities that would reduce the uptake of the drugs by non-target cells and selectively deliver the drug only to the target cells (and/or intracellular sites) at relatively low extracellular concentrations.Author: Amitabha Mukhopadhyay, Sandip K. Basu
https://link.springer.com/article/10.1007/s40820-019-0310-0
Sep 25, 2019 · It is well known that intracellular delivery of gene or protein drugs is challenging due to their rapid degradation in digestive endo-lysosomes [30, 42, 43], despite the diverse types of carriers used. Via bypassing the digestive endo-lysosomes, the developed platform maximized the intracellular delivery of miR-101.Author: Xiaofei Xin, Xiaoqing Du, Qingqing Xiao, Helena S. Azevedo, Wei He, Lifang Yin
https://www.sciencedirect.com/science/article/pii/S0169409X09003627
Surface modifications of nanocarriers for effective intracellular delivery of anti ... and rate of uptake of nanocarrier system (by internalization). The intracellular delivery of anti-HIV drugs may involve both the extracellular drug release at the interstitium (tissue site) followed by the intracellular delivery upon the internalization of ...Author: Simi Gunaseelan, Krishnan Gunaseelan, Manjeet Deshmukh, Xiaoping Zhang, Patrick J. Sinko
https://www.researchgate.net/publication/234068265_Targeted_drug_delivery_to_macrophages
Thus, macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection.
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