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https://www.fiercebiotech.com/research/oral-insulin-finally-here-thanks-to-tortoise-inspired-drug-delivery-system
Feb 07, 2019 · An oral insulin delivery system inspired by tortoises. by Angus Liu Feb 7, 2019 2:00pm. An MIT-led team has developed an oral insulin delivery platform that holds the potential to replace the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · In this review, different delivery systems intended to increase the oral bioavailability of insulin will be discussed, with a special focus on nanoparticulate carrier systems, as well as the efforts that pharmaceutical companies are making to bring to the market the first oral delivery system of insulin.Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.ncbi.nlm.nih.gov/pubmed/29501738
May 05, 2018 · Oral administration of insulin increases patient comfort and could improve glycemic control thanks to the hepatic first passage. However, challenges remain. The current approach uses poly (d, lactic-co-glycolic) acid (PLGA) nanoparticles (NPs), …Author: Elodie Czuba, Mouhamadou Diop, Carole Mura, Anais Schaschkow, Allan Langlois, William Bietiger, Roma...
https://www.sciencedirect.com/book/9781907568473/oral-delivery-of-insulin
One of the greater challenges faced by oral delivery of insulin is the reduced bioavailability. Among the different types of carrier-based delivery systems currently being pursued for oral insulin delivery, biodegradable polymeric nanoparticles have received considerable attention due to their versatility and wide range of properties.
https://www.webmd.com/diabetes/features/insulin-delivery
Oral Care; Living Well. ... Choosing an Insulin Delivery System. ... Fonseca consults with and conducts research for many of the companies that make and market insulin and insulin delivery systems ...
https://www.oramed.com/first-oral-insulin-for-diabetics-steps-towards-fda-approval/
Oramed Pharmaceuticals Inc. (NASDAQ/TASE: ORMP), a clinical-stage pharmaceutical company focused on the development of oral drug delivery systems, is working to bring the first oral insulin product to market, providing a more convenient, effective and safer method for delivering insulin therapy.
https://www.researchgate.net/publication/270654470_Oral_insulin-delivery_system_for_diabetes_mellitus
The oral insulin delivery has been proposed, however it suffers from poor bioavailability which is mainly due to the presence of proteolytic enzymes (pepsin, trypsin, and chymotrypsin) in the ...
https://www.pnas.org/content/115/28/7296
Jul 10, 2018 · Insulin is currently available as an injectable formulation, but an oral product would enjoy higher patient compliance and would significantly improve the quality of life of diabetic patients worldwide. However, oral delivery of proteins such as insulin is challenging due to various gastrointestinal barriers to oral absorption of macromolecules.Author: Amrita Banerjee, Kelly Ibsen, Kelly Ibsen, Tyler Brown, Renwei Chen, Christian Agatemor, Samir Mitra...
https://www.sciencedirect.com/science/article/pii/S0168365910006620
An oral insulin delivery system based on methyl-β-cyclodextrin (MCD) complexed insulin encapsulated polymethacrylic acid (PMAA) hydrogel microparticles was evaluated in this investigation. Poly(methacrylic acid)-chitosan-polyethylene glycol (PCP) microparticles were prepared by ionic gelation method.Author: S. Sajeesh, K. Bouchemal, V. Marsaud, C. Vauthier, Chandra P. Sharma
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