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https://www.ncbi.nlm.nih.gov/pubmed/23567010
Mar 01, 2013 · In fact, compared with this administration route, oral delivery of insulin in diabetes treatment offers many advantages: higher patient compliance, rapid hepatic insulinization, and avoidance of peripheral hyperinsulinemia and other adverse effects such as possible …Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · A previous work showed a sustained reduction of glycemia in diabetic rats treated with insulin-loaded nanoparticles for 1 to 3 weeks. 52 Until now, different studies have been carried out developing polymeric-based nanoparticles for insulin oral delivery. The polymers used may differ from their origin if they are natural or synthetic.Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.diabetesnet.com/about-diabetes/insulin/insulin-delivery/oral-insulin-delivery/
An oral tablet insulin product would do away with the above-cited limitations of injectable insulin, and inhaled insulin, in addition to the fact that oral delivery would have high patient compliance. Below are some companies currently trying to make this delivery process possible.
https://www.onlinelibrary.wiley.com/doi/full/10.1111/jphp.12852
Nov 28, 2017 · These are all factors that favour a switch to oral delivery of therapeutic peptides such as insulin. 22. Challenges in oral delivery of insulin. The fundamental barrier to the oral delivery of proteins is the gastrointestinal tract (GIT). The GIT functions as an absorptive and protective organ.Author: Ahmed Gedawy, Jorge Martinez, Hani Al‐Salami, Crispin R. Dass
https://journals.sagepub.com/doi/pdf/10.1177/193229681300700228
Oral delivery of insulin may significantly improve the quality of life of diabetes patients who routinely receive insulin by the subcutaneous route. In fact, compared with this administration route, oral delivery of insulin in diabetes treatment offers many advantages: higher patient compliance, rapid hepatic insulinization, and
https://www.novonordisk.com/about-novo-nordisk/perspectives/the-pursuit-of-oral-insulin.html
The story of oral insulin is closely linked with the discovery of the hormone itself a century ago as well as Novo Nordisk’s own history. In fact, when the co-discoverer of the molecule Frederick Banting first gave insulin to a person with diabetes in 1921, it was administered orally – though sadly without success.
https://www.researchgate.net/publication/270654470_Oral_insulin-delivery_system_for_diabetes_mellitus
Oral insulin-delivery system for diabetes mellitus. ... Oral administration of insulin may have a more physiological action than parenteral insulin. ... The oral insulin delivery has been proposed ...
https://europepmc.org/articles/PMC3737653
Mar 01, 2013 · A previous work showed a sustained reduction of glycemia in diabetic rats treated with insulin-loaded nanoparticles for 1 to 3 weeks. 52 Until now, different studies have been carried out developing polymeric-based nanoparticles for insulin oral delivery. The polymers used may differ from their origin if they are natural or synthetic.Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-015-0136-y
Oct 24, 2015 · Diabetic cases have increased rapidly in recent years throughout the world. Currently, for type-1 diabetes mellitus (T1DM), multiple daily insulin (MDI) injections is the most popular treatment throughout the world. At this juncture, researchers are trying to develop different insulin delivery systems, especially through oral and pulmonary route using nanocarrier based delivery system.Author: Garima Sharma, Garima Sharma, Ashish Ranjan Sharma, Ju-Suk Nam, George Priya C. Doss, Sang-Soo Lee, ...
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