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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787057/
Another method for delivery of insulin is fast dissolving films as an alternative to the oral tablets for rapid drug delivery. The Monosol Rx (Pharm Film Drug delivery technology) in collaboration Midatech Company developed Midaform™ insulin, which is delivered by buccal route. No information is available on studies using this formulation.
https://www.sciencedirect.com/book/9781907568473/oral-delivery-of-insulin
Abstract. The conventional and current mode of administration of insulin frequently relies on subcutaneous injection. Though the oral route is the most preferred mode of delivery, insulin cannot be administered orally due to enzymatic and chemical barriers in the stomach, degradation by proteolytic enzymes in the intestine, and poor permeability across the intestinal epithelium.
https://www.outsourcing-pharma.com/Article/2019/10/15/Novo-Nordisk-and-MIT-on-oral-delivery-of-insulin
Oct 15, 2019 · Related tags: Insulin, Oral drug delivery, Capsules, Novo nordisk. Through funding by Novo Nordisk and the NIH, researchers from MIT have come up with a microneedle containing capsule able to release drug substance into the bloodstream. The delivery method, currently under preclinical development, has the potential to offer a convenient ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737653/
Mar 01, 2013 · Furthermore, oral administration of insulin better mimics the normal insulin pathway in the body after endogenous secretion, providing a better glucose homeostasis. 8,9 In fact, oral delivery of insulin allows high portal vein concentrations, with no sustained peripheral hyperinsulinemia, which is associated with neuropathy and retinopathy. 10Author: Pedro Fonte, Francisca Araújo, Salette Reis, Bruno Sarmento
https://www.webmd.com/diabetes/features/insulin-delivery
The drug peaks in the blood in about 15-20 minutes, researchers say, and clears the body in 2-3 hours. Needle-free. Users place a dose of insulin, in powder form, into a small, whistle-sized inhaler.
https://www.researchgate.net/profile/Srinivas_Bhairy/publication/320345077_Oral_Insulin_Delivery_Novel_Strategies/links/59dee9d0458515376b2a50e7/Oral-Insulin-Delivery-Novel-Strategies.pdf
Oral Insulin Delivery: Novel Strategies Rajashree S. Hirlekar, Esha J. Patil, Srinivas R. Bhairy ... drug through the oral route. Insulin delivery via oral route is challenging as incomplete and ...
https://www.oramed.com/first-oral-insulin-for-diabetics-steps-towards-fda-approval/
Oramed Pharmaceuticals Inc. (NASDAQ/TASE: ORMP), a clinical-stage pharmaceutical company focused on the development of oral drug delivery systems, is working to bring the first oral insulin product to market, providing a more convenient, effective and safer method for delivering insulin therapy.
https://www.sciencedirect.com/science/article/pii/S0169409X98000751
This paper will focus on describing some of the literature dealing with the oral delivery of the most widely utilized protein drug, insulin. After a discussion of insulin's central position in the treatment of diabetes mellitus, general difficulties encountered with oral protein delivery will be discussed.Author: Beth A. Burnside, Carol E. Mattes, Charlotte M. McGuinness, Edward M. Rudnic, George W. Belendiuk
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