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https://www.ncbi.nlm.nih.gov/pubmed/23517644
Inhalation delivery of protein therapeutics. Kane C(1), O'Neil K, Conk M, Picha K. Author information: (1)Centyrex, Janssen Research & Development, 1400 McKean Road, Spring House, PA 19477, USA. Inhaled therapeutics are used routinely to treat a variety of pulmonary diseases including asthma, COPD and cystic fibrosis.Author: Colleen Kane, Karyn O’Neil, Michelle Conk, Kristen Picha
https://www.researchgate.net/publication/236069682_Inhalation_Delivery_of_Protein_Therapeutics
Inhalation Delivery of Protein Therapeutics. ... Inhalation delivery of doxorubicin by liposomes significantly enhanced its anticancer effect and prevented severe adverse side effects of the ...
https://www.tandfonline.com/doi/pdf/10.1080/17425247.2018.1503251
the protein significantly improved lung function. After two decades, a number of promising new inhaled protein therapeu-tics with topical lung delivery are finally reaching the clinic – especially since 2010 (Table 1). To the best of our knowledge, 18 inhaled protein therapeutics have entered clinical trials andAuthor: Elsa Bodier-Montagutelli, Alexie Mayor, Laurent Vecellio, Renaud Respaud, Nathalie Heuzé-Vourc’h
https://www.tandfonline.com/doi/abs/10.1080/17425247.2018.1503251
Dec 18, 2018 · (2018). Designing inhaled protein therapeutics for topical lung delivery: what are the next steps? Expert Opinion on Drug Delivery: Vol. 15, No. 8, pp. 729-736.Author: Elsa Bodier-Montagutelli, Alexie Mayor, Laurent Vecellio, Renaud Respaud, Nathalie Heuzé-Vourc’h
http://www.eurekaselect.com/108798/article
Keywords:Alternative scaffolds, inhalation, protein therapeutics, pulmonary delivery. Abstract:Inhaled therapeutics are used routinely to treat a variety of pulmonary diseases including asthma, COPD and cystic fibrosis. In addition, biological therapies represent the fastest growing segment of …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC58690/
Sep 25, 2001 · Inhalation delivery of proteins from ethanol suspensions is free of many inherent drawbacks of the aqueous and dry powder approaches. It is amenable to the use of standard nebulizers and should be applicable to the delivery of other macromolecular therapeutics, …Author: W. S. Choi, G. G. K. Murthy, D. A. Edwards, R. Langer, A. M. Klibanov
https://www.ondrugdelivery.com/overview-dry-powder-inhalation-systemic-drug-delivery/
Kane C, O’Neil K, Conk M, Picha K, “Inhalation delivery of protein therapeutics”. Inflammation & Allergy – Drug targets, 2013, Vol 12, pp 81-87. Mumenthaler M, Hsu CC, Pearlman R, “Feasibility study on spray-drying protein pharmaceuticals: recombinant human growth …
https://www.pnas.org/content/pnas/98/20/11103.full.pdf
much recent activity has focused on the pulmonary delivery of protein therapeutics (7–9), culminating in a clinical application, local delivery of Genentech’s recombinant human DNase (Pul-mozyme) for the treatment of cystic fibrosis (10). There are two principal means for the deep-lung inhalationAuthor: W. S. Choi, G. G. K. Murthy, D. A. Edwards, R. Langer, A. M. Klibanov
https://www.pnas.org/content/98/20/11103
Sep 25, 2001 · Abstract. To circumvent inherent problems associated with pulmonary administration of aqueous-solution and dry-powder protein drugs, inhalation delivery of proteins from their suspensions in absolute ethanol was explored both in vitro and in vivo.Protein suspensions in ethanol of up to 9% (wt/vol) were readily aerosolized with a commercial compressor nebulizer.Author: W. S. Choi, G. G. K. Murthy, D. A. Edwards, R. Langer, A. M. Klibanov
https://www.sciencedirect.com/science/article/pii/S1471489217300176
Inhalation delivery of complex drugs — the next steps. ... lastingly stunned the field of systemically inhaled protein and peptide drugs. Building on the lessons learned from these early products, a new wave of inhaled biomolecules has recently entered clinical trials. ... W.D. BennettControlled inhalation of aerosolised therapeutics.Author: Wilbur de Kruijf, Carsten Ehrhardt
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