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https://www.sciencedirect.com/science/article/pii/S0378517319308129
In order to minimise the number of injections, research on intravitreal drug delivery systems (DDSs) is needed. In this review, the DDSs developed up to date regarding intravitreal anti-VEGF drugs have been summarised, which include systems as hydrogels, liposomes, microparticles, nanoparticles or implants.Author: Andrea Luaces-Rodríguez, Andrea Luaces-Rodríguez, Cristina Mondelo-García, Irene Zarra-Ferro, Miguel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570518/
Despite significant progress in the delivery of biologics, there is unmet need to develop sustained delivery of biologics with nearly zero-order release kinetics to the back of the eye tissues. In addition, elevated intraocular pressure associated with frequent intravitreal injections of macromolecules is another concern that needs to be addressed.Author: Mary Joseph, Hoang M. Trinh, Kishore Cholkar, Dhananjay Pal, Ashim K. Mitra
https://eyewiki.aao.org/Intravitreal_Injections
Intravitreal drug delivery has become a popular method of treatment of many retinal diseases, commonly including AMD, Diabetic Retinopathy, and Retinal Vein Occlusions. The frequency of intravitreal injections has significantly increased since the introduction of Anti-VEGF medications. This is an important procedure that Retina Specialists use on a daily basis, and it is important to master ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306066/
Nov 13, 2010 · Keywords: Combination Therapy, Combined Modality Therapy, Intravitreal Delivery INTRODUCTION Combining means and therapeutics to address various pathologic processes is now a familiar topic across many, if not all, medical specialties.Author: Gholam A. Peyman, Kamran Hosseini
https://www.retinalphysician.com/issues/2020/special-edition-2020/surgical-techniques-for-retinal-gene-therapy-deliv
INTRAVITREAL DELIVERY. Intravitreal injections have become one of the most widely performed and safest ophthalmic procedures, with postinjection endophthalmitis rates as low as 0.056%. 6 Therefore, it comes as no surprise that investigators have attempted to deliver gene vector to target retinal tissues via intravitreal injection. 2
http://ufdc.ufl.edu/UFE0022065/00001
Intravitreal delivery is an effective route to de liver drugs to the posteri or region of the eye. It helps to overcome the various ocular barrie rs and the long diffusiona l distance required for attaining therapeutic con centration for posterior oc ular conditions.
https://www.retinalphysician.com/issues/2019/march-2019/prefilled-syringe-delivery-of-intravitreal-anti-ve
Mar 01, 2019 · RATIONALE FOR FREQUENT, SERIAL, CHRONIC INTRAVITREAL INJECTIONS. Patients with these diseases benefit by having available a critical level of anti-VEGF agent in the vitreous during a period of active disease; at this time, we are limited to frequent serial repeated delivery of the anti-VEGF agent via intravitreal injection.
https://www.liebertpub.com/doi/abs/10.1089/108076801753162807
Controlled Delivery of Ganciclovir to the Retina with Drug-Loaded Poly(D,L-lactide-co-glycolide) (PLGA) Microspheres Dispersed in PLGA-PEG-PLGA Gel: A Novel Intravitreal Delivery System for the Treatment of Cytomegalovirus RetinitisAuthor: David Maurice
https://www.sciencedirect.com/science/article/pii/S0168365918303146
In this paper, we propose an intravitreal implantable magnetic micropump integrated with micro check valve capable of on-demand vascular endothelial growth factor receptor (VEGFR)-targeted drug delivery for the treatment of age-related macular degeneration, diabetic retinopathy and other eye pathologies characterized by ocular neoangiogenesis.Author: Cong Wang, Seung-Jun Seo, Jin-Seong Kim, Se-Hee Lee, Jae-Kun Jeon, Jae-Woo Kim, Ki-Hong Kim, Jong-Ki...
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