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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC58690/
Sep 25, 2001 · Inhalation of relevant quantities of aerosolized ethanol by itself caused no appreciable acute toxicity. In rats, the bioavailability of insulin delivered via this approach was comparable to those observed in the inhalation delivery of insulin aqueous solutions or conventional dry powders. Inhalation delivery of proteins from ethanol suspensions is free of many inherent drawbacks of the aqueous and dry powder approaches.Author: W. S. Choi, G. G. K. Murthy, D. A. Edwards, R. Langer, A. M. Klibanov
https://www.pnas.org/content/98/20/11103
Sep 25, 2001 · Inhalation delivery of proteins from ethanol suspensions is free of many inherent drawbacks of the aqueous and dry powder approaches. It is amenable to the use of standard nebulizers and should be applicable to the delivery of other macromolecular therapeutics, e.g., nucleic acids and polysaccharides.Author: W. S. Choi, G. G. K. Murthy, D. A. Edwards, R. Langer, A. M. Klibanov
https://www.pnas.org/content/pnas/98/20/11103.full.pdf
ministration of aqueous-solution and dry-powder protein drugs, inhalation delivery of proteins from their suspensions in absolute ethanolwasexploredbothinvitroandinvivo.Proteinsuspensions in ethanol of up to 9% (wtyvol) were readily aerosolized with a commercial …Author: W. S. Choi, G. G. K. Murthy, D. A. Edwards, R. Langer, A. M. Klibanov
https://www.jstor.org/stable/3056675
ministration of aqueous-solution and dry-powder protein drugs, Nc inhalation delivery of proteins from their suspensions in absolute foI ethanol was explored both in vitro and in vivo. Protein suspensions pr(in ethanol of up to 9% (wt/vol) were readily aerosolized with a sot commercial compressor nebulizer. Experiments with enzymic pro-
https://www.ncbi.nlm.nih.gov/pubmed/11562495
Sep 25, 2001 · To circumvent inherent problems associated with pulmonary administration of aqueous-solution and dry-powder protein drugs, inhalation delivery of proteins from their suspensions in absolute ethanol was explored both in vitro and in vivo.Author: W. S. Choi, G. G. K. Murthy, D. A. Edwards, R. Langer, A. M. Klibanov
http://europepmc.org/articles/PMC58690
Sep 18, 2001 · To circumvent inherent problems associated with pulmonary administration of aqueous-solution and dry-powder protein drugs, inhalation delivery of proteins from their suspensions in absolute ethanol was explored both in vitro and in vivo.
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