In Vivo Imaging Of Oligonucleotide Delivery

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In Vivo Imaging of Oligonucleotide Delivery SpringerLink

    https://link.springer.com/protocol/10.1007/978-1-61779-797-2_17
    Mar 31, 2012 · In Vivo Imaging of Oligonucleotide Delivery. Abstract. RNA interference (RNAi) has rapidly become a powerful tool for drug-target discovery and therapeutics. Cancer is an important application for RNAi therapeutics, since abnormal gene regulation is thought to contribute to the pathogenesis and maintenance of the metastatic phenotype of cancer.Author: Fumitaka Takeshita, Ryou U. Takahashi, Jun Onodera, Takahiro Ochiya

In Vivo Imaging of Oligonucleotide Delivery Request PDF

    https://www.researchgate.net/publication/225375207_In_Vivo_Imaging_of_Oligonucleotide_Delivery
    In vivo bioluminescence imaging (BLI) is a sensitive imaging modality that is rapid and accessible, and may comprise an ideal tool for evaluating antineoplastic therapies.

In vivo imaging with oligonucleotides for diagnosis and ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867756/
    Molecular imaging, the science that combines non-invasive in vivo imaging and molecular biology, has begun to use labelled oligonucleotides as radiotracers. Antisense oligonucleotides target gene expression at the RNA level, while aptamer oligonucleotides are designed to hit proteins of interest.Author: B Tavitian

In vivo imaging of siRNA delivery and silencing in tumors ...

    https://www.nature.com/articles/nm1486
    Feb 25, 2007 · At present, reports of the in vivo imaging of siRNA in target tissues are limited to bioluminescence imaging of siRNA-mediated silencing 9,15. The assessment of siRNA delivery, however, is currently based only on ex vivo studies.Author: Zdravka Medarova, Wellington Pham, Christian Farrar, Victoria Petkova, Anna Moore

Radiolabeled oligonucleotides for antisense imaging

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148791/
    Aug 01, 2011 · iii) Delivery of antisense oligonucleotides in vivo imaging. Although antisense oligonucleotides may be invaluable agents for imaging applications, it is difficult to realize their full potential in the absence of a proper delivery system due to the barriers discussed above.Author: Arun K. Iyer, Jiang He

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