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https://www.nature.com/articles/nm1486
Feb 25, 2007 · At present, reports of the in vivo imaging of siRNA in target tissues are limited to bioluminescence imaging of siRNA-mediated silencing 9,15. …Author: Zdravka Medarova, Wellington Pham, Christian Farrar, Victoria Petkova, Anna Moore
https://www.ncbi.nlm.nih.gov/pubmed/17322898
In vivo imaging of siRNA delivery and silencing in tumors. ... new noninvasive methods for detection of siRNA delivery and silencing are urgently needed. Here we describe the development of dual-purpose probes for in vivo transfer of siRNA and the simultaneous imaging of its accumulation in tumors by high-resolution magnetic resonance imaging ...Author: Zdravka Medarova, Wellington Pham, Christian Farrar, Victoria Petkova, Anna Moore
https://www.researchgate.net/publication/6483262_In_vivo_imaging_of_siRNA_delivery_and_silencing_in_tumors
In vivo imaging of siRNA delivery and silencing in tumors ... of siRNA and the simultaneous imaging of its accumulation in tumors by high-resolution magnetic resonance imaging (MRI) and near ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191406/
Oct 13, 2014 · Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA. ... and the progression of tumors was visualized by bio-imaging and quantitatively measured at various time points. ... the challenge of siRNA in vivo delivery to the disease causing tissues and cell types has to …Author: Xiaoxia Liu, Wei Wang, Dmitry Samarsky, Li Liu, Qian Xu, Wenqing Zhang, Guangzu Zhu, Ping Wu, Xialin...
https://advances.sciencemag.org/content/6/13/eaaz6108.full
Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a wide range of biomedical applications, but there are many challenges facing its therapeutic use in vivo. Here, we report on a platelet cell membrane–coated metal-organic framework (MOF) nanodelivery platform for the targeted delivery of siRNA in vivo.
http://jnm.snmjournals.org/content/51/2/169.full
Feb 01, 2010 · A variety of molecular imaging techniques have been explored for in vivo imaging of RNAi . Clearly, continued development of noninvasive imaging strategies for monitoring both siRNA/shRNA delivery and its gene-silencing effect will provide more insights into RNAi-based therapies.
https://www.researchgate.net/publication/230687336_In_vivo_imaging_of_siRNA_electrotransfer_and_silencing_in_different_organs
In vivo imaging of siRNA electrotransfer and silencing in different organs ... in vivo siRNA delivery methods. ... for siRNA delivery and associated gene silencing into cells of solid tumors in vivo.
https://www.pnas.org/content/113/28/7750
Jul 12, 2016 · Herein, we develop an innovative theranostic NP platform using a near-infrared (NIR) fluorescent polymer for effective in vivo siRNA delivery and noninvasive NIR imaging to monitor whole-body biodistribution kinetics and tumor localization of siRNA NPs after systemic administration.Author: Yanlan Liu, Viswanath Gunda, Xi Zhu, Xiaoding Xu, Jun Wu, Diana Askhatova, Omid C. Farokhzad, Sareh ...
https://www.nature.com/articles/3302920
Mar 08, 2007 · Our study indicates that electric field can be used as an efficient method for siRNA delivery and associated gene silencing into cells of solid tumors in …Author: M Golzio, L Mazzolini, A Ledoux, A Paganin, M Izard, L Hellaudais, A Bieth, M J Pillaire, C Cazaux, ...
https://freepaper.me/downloads/abstract/10.1038/nm1486
In vivo imaging of siRNA delivery and silencing in tumors. With the increased potential of RNA interference (RNAi) as a therapeutic strategy, new noninvasive methods for detection of siRNA delivery and silencing are urgently needed.
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