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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616534/
Although RNA interference (RNAi) has become a ubiquitous laboratory tool since its discovery 12 years ago, in vivo delivery to selected cell types remains a major technical challenge. Here, we report the use of lentiviral vectors for long-term in vivo delivery of RNAi selectively to resident alveolar macrophages (AMs), key immune effector cells in the lung.Author: Andrew A Wilson, Andrew A Wilson, Letty W Kwok, Letty W Kwok, Emily L Porter, Emily L Porter, Julie ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774780/
Lentiviral vectors are potent gene delivery vehicles that enable stable expression of transgenes in both dividing and post-mitotic cells. Development of lentiviral vectors expressing small hairpin RNAs generates a system that can be used to down regulate specific target genes in vivo and in vitro.In this review, we will discuss two examples of in vivo applications for the use of lentiviral ...Author: Oded Singer, Inder M. Verma
https://www.sigmaaldrich.com/life-science/functional-genomics-and-rnai/shrna/learning-center/mission-faqs/in-vivo-faqs.html
Sigma-Aldrich® answers your frequently asked questions about in vivo RNAi applications. ... please visit our MISSION ® In Vivo and Lentiviral Solutions page. ... What are the pros/cons of in vivo vs. ex vivo delivery? There are benefits of both delivery routes. Depending on your application and research goals, one may be better than another.
https://www.sigmaaldrich.com/life-science/functional-genomics-and-rnai/shrna/in-vivo.html
Lentiviral products tailored to your in vivo research! Sigma-Aldrich® is the exclusive distributor of the RNAi Consortium (TRC) shRNA library clones in DNA or lentiviral format. Rarely, one size fits all. Your in vivo research needs are unique, so Sigma® offers multiple configurable options that are tailored to …
https://www.nature.com/articles/s41375-018-0106-0
Mar 22, 2018 · In vivo gene delivery using a lentiviral vector has also been applied clinically to the eye . These approaches face a number of hurdles including efficiency, need for tissue-restricted promoters ...Author: Michael C. Milone, Una O’Doherty
https://www.addgene.org/browse/article/7349/
Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages. Wilson AA, Kwok LW, Porter EL, Payne JG, McElroy GS, Ohle SJ, Greenhill SR, Blahna MT, Yamamoto K, Jean JC, Mizgerd JP, Kotton DN Mol Ther. 2013 Apr;21(4):825-33. doi: 10.1038/mt.2013.19. Epub 2013 Feb 12.
https://www.labome.com/method/Nucleic-Acid-Delivery-Lentiviral-and-Retroviral-Vectors.html
Lentiviral and retroviral gene delivery systems exploit aspects of retrovirus replication to provide stable integration of the desired nucleic acid sequence. Whereas transfection of nucleic acids results only in transient transgene expression, the activity of the viral integrase in retroviral and lentiviral-based systems allows for stable ...Author: Erin P O’Keefe
https://www.researchgate.net/post/Intravenous_lentivirus_delivery
Regarding the efficiency: "Despite these potential limitations, the use of intravenous lentiviral vector delivery of the ADA gene may provide a novel form of long-lasting in vivo ERT".
https://www.pnas.org/content/103/31/11479
Aug 01, 2006 · This demonstration of targeting efficient gene delivery vehicles strictly to the desired cell types in vivo greatly enhances the therapeutic potential of lentivirus-mediated gene therapy and alleviates concerns of off-target effects. Possibly the most important implication of the work is that gene therapy could now be carried out as an ...Author: Lili Yang, Leslie Bailey, David Baltimore, Pin Wang
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