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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850243/
Aug 08, 2013 · RNA interference (RNAi) has considerable potential as a therapeutic strategy, but the development of efficient in vivo RNA delivery methods remains challenging. To this end, we designed and synthesized chemically modified interfering nanoparticles (iNOPs) composed of functionalized poly- l -lysine dendrimers modified with reducible spacers to facilitate release of small interfering RNAs (siRNAs) in vivo.Author: Huricha Baigude, Jie Su, Joshua McCarroll, Tariq M. Rana
https://pubs.acs.org/doi/10.1021/ml4001003
For the application of RNA interference (RNAi) in vivo the functional delivery of short interfering RNAs (siRNAs) is still the major obstacle. Therefore, delivery technologies need to be established for the systemic application of RNAi in vivo.Author: Huricha Baigude, Jie Su, Joshua McCarroll, Tariq M. Rana
https://pubs.acs.org/doi/pdf/10.1021/ml4001003
efficient in vivo RNA delivery methods remains challenging. To this end, we designed and synthesized chemically modified interfering nanoparticles (iNOPs) composed of functionalized poly-L-lysine dendrimers modified with reducible spacers to facilitate release of small interfering RNAs (siRNAs) in vivo.
https://pubs.acs.org/doi/suppl/10.1021/ml4001003/suppl_file/ml4001003_si_001.pdf
In Vivo Delivery of RNAi by Reducible Interfering Nanoparticles (iNOPs) Huricha Baigude †‡ , Jie Su ‡¶ , Joshua McCarroll‡§, and Tariq M Rana †‡ * †Program for RNA Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037
https://www.researchgate.net/publication/259250152_In_Vivo_Delivery_of_RNAi_by_Reducible_Interfering_Nanoparticles_iNOPs
For the application of RNA interference (RNAi) in vivo the functional delivery of short interfering RNAs (siRNAs) is still the major obstacle.
https://core.ac.uk/display/108148149
RNA interference (RNAi) has considerable potential as a therapeutic strategy, but the development of efficient in vivo RNA delivery methods remains challenging. To this end, we designed and synthesized chemically modified interfering nanoparticles (iNOPs) composed of functionalized poly-l-lysine dendrimers modified with reducible spacers to facilitate release of small interfering RNAs (siRNAs) in vivo.Author: H Baigude, J Su, J McCarroll and TM Rana
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