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https://www.researchgate.net/publication/51190095_In_Vivo_Delivery_of_RNAi_with_Lipid-Based_Nanoparticles
Proper delivery of siRNAs by lipid-based nanoparticles or encapsulation of siRNA into PEGylated nanoliposomes, both lead to downregulation of P-gp expression in doxorubicin-resistant breast cancer ...
https://www.ncbi.nlm.nih.gov/pubmed/21639780
Aug 15, 2011 · The major challenge for RNAi-based therapy is the delivery system that meets human therapeutic needs. Therefore, engineering vectors with good delivery efficiency and safety profile is an intense area of research. Lipid-based nanoparticles for RNAi have yielded successful advances in vivo and to an extent in clinical trials.Author: Leaf Huang, Yang Liu
https://www.annualreviews.org/doi/full/10.1146/annurev-bioeng-071910-124709
The major challenge for RNAi-based therapy is the delivery system that meets human therapeutic needs. Therefore, engineering vectors with good delivery efficiency and safety profile is an intense area of research. Lipid-based nanoparticles for RNAi have yielded successful advances in vivo and to …
https://www.nature.com/articles/ncomms5277
Jun 27, 2014 · Figure 3: In vivo siRNA delivery activity of lipidoid nanoparticles. ( a ) Of the ~100 lipidoids tested in mice, 15 induced high levels of Factor VII knockdown at a …Author: Kathryn A. Whitehead, Kathryn A. Whitehead, J Robert Dorkin, Arturo J. Vegas, Philip H. Chang, Omid ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207430/
In vivo endothelial siRNA delivery using polymeric nanoparticles with low ... differs from traditional lipid-based nanoparticle formulations by delivering siRNA to lung endothelial cells without substantially reducing gene expression in pulmonary immune cells, hepatocytes, or peritoneal immune cells, at low doses. ... this is the first ...Author: James E. Dahlman, Carmen Barnes, Omar F. Khan, Aude Thiriot, Siddharth Jhunjunwala, Taylor E. Shaw, ...
https://www.sciencedirect.com/science/article/pii/S2162253120300536
The efficient delivery of antisense oligonucleotides (ASOs) to the targeted cells and organs remains a challenge, in particular, in vivo.Here, we investigated the ability of a library of biodegradable lipid nanoparticles (LNPs) in delivering ASO to both cultured human cells and animal models.Author: Liu Yang, Feihe Ma, Fang Liu, Jinjin Chen, Xuewei Zhao, Qiaobing Xu
https://www.medscape.com/viewarticle/818963
Oct 25, 2019 · This review discusses the hurdles of systemic siRNA delivery and highlights the recent progress made in lipid-based nanoparticles, which are categorized based on their key lipid components ...
https://www.deepdyve.com/lp/annual-reviews/in-vivo-delivery-of-rnai-with-lipid-based-nanoparticles-g221IQMM0z
Aug 15, 2011 · Read "In Vivo Delivery of RNAi with Lipid-Based Nanoparticles, Annual Review of Biomedical Engineering" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.nature.com/articles/s41434-019-0095-2
Jul 12, 2019 · We postulate that the ionization of the lipid caused lower retention of the RNA, which then resulted in lower transfection and in vivo delivery efficiencies, as confirmed by the failure to induce ...Author: Anna K. Blakney, Paul F. McKay, Bárbara Ibarzo Yus, Yoann Aldon, Robin J. Shattock
https://www.sciencedirect.com/science/article/pii/B9780128133392000165
Overcoming the challenging pharmacokinetics of siRNAs using different strategies, including lipid-based delivery systems, has required an enormous effort, which has shaped the current landscape of RNAi medicines progressing through clinical development, focusing on the liver as the major target organ.Author: Nuno A. Fonseca, Rui M. Lopes, Ana F. Cruz, Ana C. Gregório, Ângela Valério-Fernandes, Vera Moura, S...
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