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https://www.ncbi.nlm.nih.gov/pubmed/8787855
Implantable pumps for drug delivery to the brain. Bakhshi S(1), North RB. Author information: (1)Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA. This article reviews the role of implantable pumps in the treatment of CNS tumors.Author: Sanjay Bakhshi, Richard B. North
https://link.springer.com/article/10.1007/BF01060219
Nov 01, 1995 · This article reviews the role of implantable pumps in the treatment of CNS tumors. Systemic administration of chemotherapeutic agents has been associated with various problems, including adverse systemic effects and decreased concentration of the drug at the target site. Continuous infusion of chemotherapeutic agents with implantble pumps have been used in an attempt to …Author: Sanjay Bakhshi, Richard B. North
https://www.sciencedirect.com/science/article/pii/B9780128136652000132
Brain, prostate, and bladder cancer are a few examples, for which attempts have been made to enable treatment with a drug delivery implant (Barros et al., 2016, Exner and Saidel, 2008). The Gliadel Wafer described earlier has been approved as one of the first implantable brain cancer treatment to deliver chemotherapy directly to the tumor site.Author: Anoop Kumar, Jonathan Pillai
https://promedmolding.com/implantable-drug-delivery-devices-overview/
Dec 18, 2017 · Implantable drug delivery devices offer several advantages over conventional oral or parenteral dosage forms. First, implantable devices allow site specific drug administration where the drug is most needed. Examples include implants used in the treatment of brain tumors (Gliadel® wafer) or prostate cancer (Lupron® depot).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576846/
Implantable drug-delivery devices. Implantable drug infusion pumps have been in use for many years and for both preclinical and clinical applications. Typical implantable systems possess three fundamental components: drug container, drug release mechanism and an implantable packaging.Author: Ellis Meng, Tuan Hoang
https://www.researchgate.net/publication/319327771_Implantable_drug_delivery_systems_An_Overview
Implantable drug delivery systems offer physicians the choice of precision delivery, either locally or into systemic circulation, while guaranteeing optimal dosing over the course of treatment.The ...
https://www.pharmatutor.org/articles/review-implantable-drug-delivery-system
Therefore, drug delivery systems were developed to optimize the therapeutic properties of drug products and render them more safe, effective, and reliable. In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery are at a crude stage of development.
https://www.inverse.com/article/40509-minds-drug-delivery-parkinsons
Jan 24, 2018 · New Tiny Implanted Pumps Can Inject Drugs Directly Into Brains ... The most obvious one is that implanting a deep brain drug delivery device is invasive as heck. This is not a simple procedure ...Author: Peter Hess
https://www.medtronic.com/us-en/patients/treatments-therapies/drug-pump-chronic-pain.html
OVERVIEW TARGETED DRUG DELIVERY. Patients report a reduction in pain scores after receiving targeted drug delivery. 51% of patients completely eliminated other opioids* at 12 months. 1 87% of patients rated their quality of life as fair to excellent. 2 90% of patients would recommend therapy to a family member or friend. 2
https://www.fda.gov/medical-devices/safety-communications/use-caution-implanted-pumps-intrathecal-administration-medicines-pain-management-fda-safety
Nov 14, 2018 · Pain medicines approved by FDA for delivery into the spinal fluid must meet additional safety standards because the spinal cord and brain tissue are …
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