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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Keywords: Chemical delivery, gene therapy, non viral delivery systems, physical delivery, viral delivery systems INTRODUCTION Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[ 1 ]
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Since the initial studies, hundreds of cationic lipids have been synthesized as candidates for non-viral gene delivery and a few made it to clinical trials [85,86]. Cationic lipids can be used to form lipoplexes by directly mixing the positively charged lipids at the physiological pH with the negatively charged DNA.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes . Non-viral vectors have drawn significant attention due to its less immunotoxicity.Author: Murali Ramamoorth, Aparna Narvekar
http://juventasinc.com/non-viral-gene-therapy.html
Gene therapy generally refers to the delivery of DNA into a patient’s cells to treat a target disease. The two major classes of gene therapy are viral, which uses recombinant viruses to promote long-term or permanent genomic modification, and non-viral, which uses a naked DNA plasmid to promote short-term therapeutic protein expression locally at the site of drug administration.
https://www.nature.com/articles/3302838
Sep 05, 2006 · As the success of gene therapy is highly dependent on the delivery vector, research in this field has been focused on the development of a suitable delivery system. Investigators of non-viral...Author: Li Sd, Huang L
https://www.nature.com/articles/3302692
Dec 01, 2005 · Two of the main reasons why gene therapy has not been globally successful in the clinic are the inefficient delivery of nucleic acids to their correct intracellular sites of action and the poor...Author: S Akhtar
http://www.genetherapynet.com/non-viral-vectors.html
Non-Viral Vectors Non-viral methods present certain advantages over viral methods, with simple large scale production and low host immunogenicity being just two. Previously, low levels of transfection and expression of the gene held non-viral methods at a disadvantage; however, recent advances in vector technology have yielded molecules and techniques with transfection efficiencies similar to …
https://www.sciencedirect.com/science/article/pii/S0168365915302649
Non-viral gene delivery systems are engineered complexes or nanoparticles (NPs) composed of the required nucleic acid (plasmid, RNA, oligonucleotides) and a single or a combination of materials such as cationic lipids, surfactants, peptides, polysaccharides, metals (gold, magnetic iron) and synthetic polymers (poly(dl -lactide-co-glycolide acid) (PLGA), polyethyleneimine (PEI), polyamidoamine dendrimer …Author: Marianna Foldvari, Ding Wen Chen, Nafiseh Nafissi, Daniella Calderon, Lokesh Narsineni, Amirreza Raf...
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