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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722627/
Although gene therapy as a treatment for disease holds great promise, progress in developing effective clinical protocols has been slow. The problem lies in the development of safe and efficient gene-delivery systems. This review will evaluate the problems and the potential solutions in this new field of medicine.
https://engene.com/press/2019/BioPharma.pdf
Pioneering oral delivery for gene therapy enGene has developed a proprietary nonviral gene delivery platform and Gene Pill technology to deliver orally administered gene therapies to mucosal tissues, creating new opportunities for treating hard-to-reach tissues across many indications. Mucosal tissues are challenging to treat using current
https://www.sciencedaily.com/releases/2008/05/080520163044.htm
May 22, 2008 · Northeastern University. (2008, May 22). Gene Therapy: Oral Gene Delivery System For Inflammatory Bowel Disease Works, Study Shows. ScienceDaily. Retrieved March 27, 2020 from www.sciencedaily.com ...
https://biopharmadealmakers.nature.com/users/262926-engene/documents/49814-engene-june-2019
Jun 10, 2019 · Pioneering oral delivery for gene therapy. ... Oral gene delivery is a revolutionary improvement over current protein-drug delivery methods which involve injections and represent risks of side effects, high cost, poor patient compliance and systemic problems due to the need to administer higher doses. The company is evolving its technology to ...
https://www.sciencedirect.com/science/article/pii/S2468451118300254
Non-viral gene delivery via the oral route is a promising strategy for improving outcomes of DNA vaccination and gene therapy applications. Unlike traditional parenteral administration routes, the oral route is a non-invasive approach that lends itself to high patient compliance and ease of dosing.Author: Eric Farris, Kari Heck, Anna T. Lampe, Deborah M. Brown, Amanda E. Ramer-Tait, Angela K. Pannier
https://engene.com/science/
Jul 10, 2017 · The delivered sequences can encode proteins, peptides, antibodies, and the like. Importantly, we have formulated our proprietary DNA delivery system into a Gene Pill™ to provide oral delivery of therapeutic genes to the gut – a game-changing technology that enables oral delivery of protein therapeutics.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/nucleic-acid-delivery
H. Montazeri Aliabadi, in Polymers and Nanomaterials for Gene Therapy, 2016. Abstract. Nucleic acid delivery presents unique challenges that could be entirely different compared to small molecules due to their molecular size, electric charge, and significant susceptibility to enzymatic degradation. However, some of the basic principles could be applied to both fields, which means specific ...
https://blog.dana-farber.org/insight/2018/04/gene-therapy-used-treat-cancer/
Apr 02, 2018 · Gene therapy alters the genetic instructions within an individual’s cells. A gene is a sequence of DNA — pictured above. A variety of efforts are underway to apply gene therapy to cancer treatment. Most are in early, exploratory stages, where they’re …
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201701079
Efficient nonviral oral gene delivery offers an attractive modality for chronic protein replacement therapy. Herein, the oral delivery of insulin gene is reported by a nonviral vector comprising a copolymer with a high degree of substitution of branched polyethylenimine on chitosan (CS‐g‐bPEI).Author: Po Yen Lin, Ya Ling Chiu, Ya Ling Chiu, Jing Huei Huang, Er Yuan Chuang, Fwu Long Mi, Kun Ju Lin, Jy...
http://www.nature.com/articles/gt200867
Apr 17, 2008 · The objective of this study was to examine the potential of oral interleukin-10 (IL-10) gene therapy for the treatment of inflammatory bowel disease (IBD). Nanoparticles-in-microsphere oral …Author: Bhavsar, M M Amiji
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