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https://www.nextbigfuture.com/2013/05/nasal-spray-gene-therapy-could-protect.html
Nasal Spray gene therapy could protect against flu and pandemic flu. Nasal Spray gene therapy could protect against flu and pandemic flu. ... (AAV) can serve as a gene delivery vehicle to treat inherited diseases like cystic fibrosis and hemophilia. Gates, whose foundation focuses on global health, “asked me whether the AAV-mediated approach ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · A more definitive study directly comparing sumatriptan delivery with a breath-powered Bi-Directional™ device to delivery by standard nasal spray, oral delivery, and injection delivery is being conducted and should report results soon (www.clinicaltrials.gov).Author: Per Gisle Djupesland
https://experts.umn.edu/en/publications/intranasal-adeno-associated-virus-mediated-gene-delivery-and-expr
Intranasal Adeno-Associated Virus Mediated Gene Delivery and Expression of Human Iduronidase in the Central Nervous System : A Noninvasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type i.Author: Lalitha R. Belur, Alexa Temme, Kelly M. Podetz-Pedersen, Maureen Riedl, Lucy Vulchanova, Nicholas Ro...
https://hscweb3.hsc.usf.edu/blog/2019/12/04/nose-to-brain-delivery-of-nanoparticles-lowers-huntingtons-disease-gene-expression/
Seeking to optimize HD gene silencing when the siRNA is delivered by a nasal route, the team tested different formulations and sizes of the nanoparticles in a mouse model expressing the human HD gene. Among their findings: — Four different versions of the nanoparticles tested lowered HD gene expression in the brain by 50%.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134927/
Apr 01, 2005 · Gene therapy holds promise for the treatment of a range of inherited diseases, such as cystic fibrosis. However, efficient delivery and expression of the therapeutic transgene at levels sufficient to result in phenotypic correction of cystic fibrosis pulmonary disease has proved elusive.Author: Tim W. R. Lee, Tim W. R. Lee, David A. Matthews, G. Eric Blair
https://www.medscape.com/viewarticle/847433
Sep 30, 2019 · Liposome-based delivery of the CFTR gene sequence improved lung function in patients with cystic fibrosis treated monthly for a year. ... in a nasal spray or underwent bronchoscopy before the ...
https://www.sciencedirect.com/science/article/pii/S0361923018303678
Models of nasal drug delivery can be used for detecting and testing nasal drug absorption and permeation, for PK/PD studies, toxicological and electrophysiological studies, and also for assessment of drug transporter interaction and the nasal barrier. Models commonly used in nasal drug delivery experiments are in vitro, in vivo and ex vivo ...Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
https://quizlet.com/111516604/chapter-20-practice-problems-final-flash-cards/
Gene therapy is currently under investigation as a possible way to cure cystic fibrosis. How is the viral vector carrying the normal gene delivered to the affected cells? A) bacterial plasmid B) application to skin C) ingestion D) injection E) nasal spray
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