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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801296/
Mar 15, 2016 · Cre Protein Delivery-Mediated Gene Recombination. The resulting DsRed expression from successful Cre-mediated recombination in (–27)GFP-Cre lipid nanoparticle-treated HeLa-DsRed cells was analyzed 24 h after protein delivery. As shown in Fig. 3B, (–27)GFP-Cre alone is incapable of inducing DsRed expression.Author: Ming Wang, John Zuris, Fantao Meng, Holly Anne Rees, Shuo Sun, Pu Deng, Yong Han, Xue Gao, Dimitra P...
https://pubs.acs.org/doi/abs/10.1021/acsnano.7b02884
Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic strategies. We report a general strategy for efficient delivery of proteins to the cytosol through co-engineering of proteins and nanoparticle vehicles.Author: Rubul Mout, Moumita Ray, Tristan Tay, Kanae Sasaki, Gulen Yesilbag Tonga, Vincent M. Rotello
https://link.springer.com/content/pdf/10.1208%2Fs12249-019-1325-z.pdf
peptide and protein drugs, most of the nanoparticle delivery system can help overcome many of the barriers encountered in following oral administration including enzymatic degra-dation and poor membrane permeability (11,19). There are some specifitissues related to immunity in the intestines ofc humans and animals, such as Peyer’s patches.Author: Shu-jun Cao, Shuo Xu, Hui-ming Wang, Yong Ling, Jiahua Dong, Rui-dong Xia, Xiang-hong Sun
https://www.sciencedirect.com/science/article/pii/S0168365915301802
This review summarizes marketed protein delivery strategies, recent progress in intracellular protein delivery, design considerations of nanoparticle technologies and their advancement on systemic protein delivery, and the application of nanotechnology to develop non-injectable protein therapeutics that can enhance patient satisfaction and ...Author: Mikyung Yu, Jun Wu, Jinjun Shi, Omid C. Farokhzad, Omid C. Farokhzad
https://pubs.acs.org/doi/10.1021/acs.accounts.8b00493
Moreover, we optimized the chemical structure of lipids to control lipid degradation and protein release inside cells for CRISPR/Cas9 genome-editing protein delivery.In the second part of this Account, we survey our recent endeavor in developing a chemical approach to modify protein, in particular, coupled with the nanoparticle delivery ...Author: Jin Chang, Xianghan Chen, Xianghan Chen, Zachary Glass, Feng Gao, Lanqun Mao, Ming Wang, Qiaobing Xu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962404/
May 21, 2018 · Significantly, the authors have demonstrated a highly efficient gene editing strategy based on the co-delivery of the Cas9 protein and sgRNA into mammalian cells using this nanoparticle-protein nanocomposite delivery approach. 44 In this work, the authors have inserted E-tags at the N-terminus of Cas9, and also appended a nuclear localization ...Author: Federica Scaletti, Joseph Hardie, Yi-Wei Lee, David C. Luther, Moumita Ray, Vincent M. Rotello
https://www.researchgate.net/publication/304814091_Synthesis_of_protein_nanoparticles_for_drug_delivery
Along with the nanoparticles for drug delivery, various nanoformulation synthesis methods have also been explored to increase the therapeutic efficiency.
https://advances.sciencemag.org/content/5/12/eaay3255.full
Dec 01, 2019 · Efficient cytosolic protein delivery is necessary to fully realize the potential of protein therapeutics. Current methods of protein delivery often suffer from low serum tolerance and limited in vivo efficacy. Here, we report the synthesis and validation of a previously unreported class of carboxylated branched poly(β-amino ester)s that can self-assemble into nanoparticles for efficient ...Author: Yuan Rui, David R. Wilson, John Choi, Mahita Varanasi, Katie Sanders, Johan Karlsson, Michael Lim, J...
https://www.nature.com/articles/s41467-018-06979-4
Oct 31, 2018 · Protein corona shield nanoparticle (PCSN). a We introduce the protein corona shield (PCS) concept for an efficient target drug delivery system. Generally, nanoparticle drug carriers with a …Author: Jun Yong Oh, Han Sol Kim, L. Palanikumar, Eun Min Go, Batakrishna Jana, Soo Ah Park, Ho Young Kim, K...
https://www.hindawi.com/journals/bmri/2014/180549/
In this paper, we review the most significant advancements in protein nanoparticle technology and their use in drug delivery arena. We then examine the various sources of protein materials that have been used successfully for the construction of protein nanoparticles as well as their methods of preparation.Author: Warangkana Lohcharoenkal, Liying Wang, Yi Charlie Chen, Yon Rojanasakul
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