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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828182/
Sep 22, 2009 · Functional Delivery of siRNA in Mice Using Dendriworms. ... of dendrimer-conjugated magnetofluorescent nanoworms that we call “dendriworms” as a modular platform for siRNA delivery in vivo. This platform maximizes endosomal escape to robustly produce protein target knockdown in vivo, and is tolerated well in mouse brain. We demonstrate that ...Author: Amit Agrawal, Dal Hee Min, Neetu Singh, Haihao Zhu, Alona Birjiniuk, Geoffrey Von Maltzahn, Todd J. ...
https://pubs.acs.org/doi/full/10.1021/nn900201e
Functional Delivery of siRNA in Mice Using Dendriworms. ... We evaluated the utility of dendriworm-based siRNA delivery in mice. When dendriworms (20 μg of iron in 100 μL of 1× PBS) were injected in the bloodstream via tail vein injections, preferential accumulation in the lungs, ...Author: Amit Agrawal, Dal Hee Min, Neetu Singh, Haihao Zhu, Alona Birjiniuk, Geoffrey Von Maltzahn, Todd J. ...
http://lmrt.mit.edu/sites/default/files/Agrawal_ACSNano_2009_0.pdf
siRNA delivery reports use a model gene to demonstrate knockdown in non-native tis-sues of animals, which may not be equiva-lent to a native disease model. Overall, while the above reports highlight signifi-cant advances in siRNA delivery, there is a need for a versatile siRNA delivery vehicle *Address correspondence to [email protected].
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/performing-rnai-experiments-in-animals.html
More recently, low volume, normal pressure intravenous delivery of a modified siRNA targeting apolipoprotein B in mice resulted in gene silencing in the liver and jejunum. The siRNA was conjugated with cholesterol to provide targeted delivery, and included backbone and sugar modifications to enhance serum stability [6].
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.208.2840
BibTeX @MISC{Agrawal09functionaldelivery, author = {Amit Agrawal and Dal-hee Min and Neetu Singh and Haihao Zhu and Alona Birjiniuk and Geoffrey Von Maltzahn and Todd J. Harris and Deyin Xing and Stephen D. Woolfenden and Phillip A. Sharp and Alain Charest and Sangeeta Bhatia}, title = {Functional Delivery of siRNA in Mice Using Dendriworms}, year = {2009}}
https://www.researchgate.net/publication/26735028_Functional_Delivery_of_siRNA_in_Mice_Using_Dendriworms
It was shown that these delivery systems encapsulating siRNA against EGFR show 70 % gene silencing in vitro and signifi cant down-regulation of EGFR in a transgenic mouse model of glioblastoma.
https://lmrt.mit.edu/publications/functional-delivery-sirna-mice-using-dendriworms
Not surprisingly, their use for treatment of diseases that are rooted in aberrant gene expression, such as cancer, has become a paradigm that has gained wide interest. Here, we report the development of dendrimer-conjugated magnetofluorescent nanoworms that we call "dendriworms" as a modular platform for siRNA delivery in vivo.
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