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https://www.sciencedirect.com/science/article/pii/S0167779997011700
The oral route represents one of the most attractive and acceptable routes for the administration of therapeutical compounds. The oral delivery of drugs and proteins would avoid the pain and discomfort associated with injections, and would also eliminate the possibility of infections caused by …Author: Alessio Fasano
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(97)01170-0
Apr 01, 1998 · Conventional forms of administration for nonabsorbable drugs and peptides often rely on parenteral injection, because the intestinal epithelium represents a major barrier to the oral absorption of these therapeutic agents. Recently, a number of innovative drug-delivery approaches have been developed, including entrapment within small vesicles and passage through the space between …Author: Alessio Fasano
https://www.sciencedirect.com/science/article/abs/pii/S0167779997011700
This article reviews some of the most promising techniques currently available for oral delivery and their possible practical applications for the delivery of vaccines and drugs for the treatment of clinical conditions that require frequent, chronic parenteral administration.Author: Alessio Fasano
https://www.ncbi.nlm.nih.gov/pubmed/9586237
1. Trends Biotechnol. 1998 Apr;16(4):152-7. Innovative strategies for the oral delivery of drugs and peptides. Fasano A(1). Author information: (1)Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore 21201, USA. Conventional forms of administration for nonabsorbable drugs and peptides often rely on parenteral injection, because the ...Author: Alessio Fasano
https://link.springer.com/article/10.2165/00063030-200519030-00003
Aug 15, 2012 · The main reasons for the low oral bioavailability of peptide drugs are pre-systemic enzymatic degradation and poor penetration of the intestinal mucosa. A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs.Author: Josias H. Hamman, Gill M. Enslin, Awie F. Kotzé
https://www.cell.com/trends/biotechnology/pdf/S0167-7799(97)01170-0.pdf
Innovative strategies for the oral delivery of drugs and peptides Alessio Fasano Conventional forms of administration for nonabsorbable drugs and peptides often rely on parenteral injection, because the intestinal epithelium represents a major barrier to the oral absorption of these therapeutic agents. Recently, a number of
https://www.ondrugdelivery.com/innovative-smart-oral-delivery-technology-proteins-peptides/
The formulation of proteins and peptides as oral dosage forms. requires advanced drug delivery strategies to overcome physiological challenges of the gastrointestinal tract, including enzymatic degradation, poor permeability and large molecular size 4 and …
https://www.deepdyve.com/lp/elsevier/innovative-strategies-for-the-oral-delivery-of-drugs-and-peptides-NJlhT0bBLA
Innovative strategies for the oral delivery of drugs and peptides Innovative strategies for the oral delivery of drugs and peptides Fasano, Alessio 1998-04-01 00:00:00 Conventional forms of administration for nonabsorbable drugs and peptides often rely on parenteral injection, because the intestinal epithelium represents a major barrier to the oral absorption of these therapeutic agents.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792531/
To overcome these barriers, several formulation strategies are being investigated. Here, we discuss the use of enteric-coated dry emulsions, microspheres, liposomes and nanoparticles for oral delivery of peptides and proteins. Emulsions protect drug from chemical and enzymatic breakdown in …
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
Citation: Fureby A, Elofsson U, Gerde P, “Pulmonary Delivery of Antimicrobial Peptides”. ONdrugDelivery Magazine, Issue 57 (Apr 2015), pp 4-7. Anna Fureby, Ulla Elofsson and Per Gerde discuss the serious problem of antibiotic resistance and the potential role of antimicrobial peptides in the treatment of resistant bacterial strains.
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