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https://www.pnas.org/content/115/42/E9944
Oct 16, 2018 · Nanoparticle-mediated delivery of siRNA to hepatocytes has treated disease in humans. However, systemically delivering RNA drugs to nonliver tissues remains an important challenge. To increase the number of nanoparticles that could be studied in vivo, we designed a high-throughput method to measure how >100 nanoparticles delivered mRNA that was translated into functional …Author: Cory D. Sago, Melissa P. Lokugamage, Kalina Paunovska, Daryll A. Vanover, Christopher M. Monaco, Nir...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828182/
Sep 22, 2009 · Functional Delivery of siRNA in Mice Using Dendriworms ... complementary mRNA sequences and thus regulate gene expression. Not surprisingly, their use for treatment of diseases that are rooted in aberrant gene expression, such as cancer, has become a paradigm that has gained wide interest. ... delivery of intact, functional siRNAs into the ...Author: Amit Agrawal, Dal Hee Min, Neetu Singh, Haihao Zhu, Alona Birjiniuk, Geoffrey Von Maltzahn, Todd J. ...
https://www.nature.com/articles/nbt.1733
Jan 09, 2011 · Here we investigate the therapeutic utility of chemically modified mRNA as an alternative to DNA-based gene therapy. ... in a physiologically functional model in ... proteins after delivery of ...Author: Michael S D Kormann, Günther Hasenpusch, Manish K Aneja, Gabriela Nica, Andreas W Flemmer, Susanne H...
https://www.pnas.org/content/pnas/115/42/E9944.full.pdf
tdTomato (Ai14) mice (27). Ai14 cells fluoresce if Cre mRNA is translated into Cre protein, which then translocates to the nu-cleus and edits target DNA. We isolated tdTomato+ cells with Fig. 1. FIND is a high-throughput screen for functional mRNA delivery. (A) Unlike previous biodistribution screens, which cannot distinguish between boundAuthor: Cory D. Sago, Melissa P. Lokugamage, Kalina Paunovska, Daryll A. Vanover, Christopher M. Monaco, Nir...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443240/
The concept of using exogenous mRNA to express protein can be traced back to 1978, when the first attempt was to deliver rabbit globin mRNA using liposomes to mouse lymphocytes and yield functional proteins (Dimitriadis, 1978).Over the next decade, however, mRNA was not applied as a therapeutic agent due to several concerns such as instability, poor cell penetration, immunogenicity as well as ...Author: Bin Li, Xinfu Zhang, Yizhou Dong
https://pubs.acs.org/doi/10.1021/acs.biomac.7b01356
Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers. ... PE4K-A17-0.33C12 mRNA NPs enabled luciferase expression predominantly in the lungs after intravenous injection into mice. The efficient mRNA delivery specifically to lungs by degradable carriers suggests the potential for the treatment of pulmonary diseases. ...Author: Yunfeng Yan, Yunfeng Yan, Hu Xiong, Xinyi Zhang, Qiang Cheng, Daniel John Siegwart
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