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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828182/
Sep 22, 2009 · Convection-Enhanced Intracranial Delivery of EGFR siRNA Using Dendriworms Reduces EGFR Expression in GBM Tumors. Given the efficacy of RNA interference in GBM cells in vitro, we studied the effects of siRNA delivery by dendriworms to the brain parenchyma. First, we determined the biodistribution within CNS tissues of healthy CD-1 outbred mice ...Author: Amit Agrawal, Dal Hee Min, Neetu Singh, Haihao Zhu, Alona Birjiniuk, Geoffrey Von Maltzahn, Todd J. ...
https://pubs.acs.org/doi/10.1021/nn900201e
Small interfering RNAs (siRNAs) mediate cleavage of specific, complementary mRNA sequences and thus regulate gene expression. Not surprisingly, their use for treatment of diseases that are rooted in aberrant gene expression, such as cancer, has become a paradigm that has gained wide interest. Here, we report the development of dendrimer-conjugated magnetofluorescent nanoworms that we call ...Author: Amit Agrawal, Dal Hee Min, Neetu Singh, Haihao Zhu, Alona Birjiniuk, Geoffrey Von Maltzahn, Todd J. ...
http://lmrt.mit.edu/sites/default/files/Agrawal_ACSNano_2009_0.pdf
siRNA delivery reports use a model gene to demonstrate knockdown in non-native tis-sues of animals, which may not be equiva-lent to a native disease model. Overall, while the above reports highlight signifi-cant advances in siRNA delivery, there is a need for a versatile siRNA delivery vehicle *Address correspondence to [email protected].
https://pubs.acs.org/doi/full/10.1021/nn900201e
A recent report demonstrates use of generation 7 PAMAM dendrimers for siRNA delivery, but most efforts using lower generation dendrimers for siRNA delivery have been unsuccessful and it has been shown that lower generation dendrimers are poor at forming uniform, stable particles with siRNAs.Author: Amit Agrawal, Dal Hee Min, Neetu Singh, Haihao Zhu, Alona Birjiniuk, Geoffrey Von Maltzahn, Todd J. ...
https://www.researchgate.net/publication/26735028_Functional_Delivery_of_siRNA_in_Mice_Using_Dendriworms
Request PDF Functional Delivery of siRNA in Mice Using Dendriworms Small interfering RNAs (siRNAs) mediate cleavage of specific, complementary mRNA sequences and …
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.208.2840
BibTeX @MISC{Agrawal09functionaldelivery, author = {Amit Agrawal and Dal-hee Min and Neetu Singh and Haihao Zhu and Alona Birjiniuk and Geoffrey Von Maltzahn and Todd J. Harris and Deyin Xing and Stephen D. Woolfenden and Phillip A. Sharp and Alain Charest and Sangeeta Bhatia}, title = {Functional Delivery of siRNA in Mice Using Dendriworms}, year = {2009}}
http://dspace.mit.edu/handle/1721.1/65351
Not surprisingly, their use for treatment of diseases that are rooted in aberrant gene expression, such as cancer, has become a paradigm that has gained wide interest. Here, we report the development of dendrimer-conjugated magnetofluorescent nanoworms that we call “dendriworms” as a modular platform for siRNA delivery in vivo.
https://lmrt.mit.edu/publications/functional-delivery-sirna-mice-using-dendriworms
Not surprisingly, their use for treatment of diseases that are rooted in aberrant gene expression, such as cancer, has become a paradigm that has gained wide interest. Here, we report the development of dendrimer-conjugated magnetofluorescent nanoworms that we call "dendriworms" as a modular platform for siRNA delivery in vivo.
https://www.academia.edu/7117379/Functional_Delivery_of_siRNA_in_Mice_Using_Dendriworms
Functional Delivery of siRNA in Mice Using Dendriworms
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/performing-rnai-experiments-in-animals.html
More recently, low volume, normal pressure intravenous delivery of a modified siRNA targeting apolipoprotein B in mice resulted in gene silencing in the liver and jejunum. The siRNA was conjugated with cholesterol to provide targeted delivery, and included backbone and sugar modifications to enhance serum stability [6].
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