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https://www.sciencedirect.com/science/article/pii/S1359644600015944
Understandably, most of what is known regarding the mechanistic utility of folate-mediated macromolecule delivery has come from experiments performed in vitro. Molecules ranging in size from amino acids to liposome–DNA complexes (<200 nm diameter) have successfully been targeted to and endocytosed within FR-expressing cells.Author: Christopher P. Leamon, Philip S. Low
https://www.ncbi.nlm.nih.gov/pubmed/11165172
Jan 01, 2001 · 1. Drug Discov Today. 2001 Jan 1;6(1):44-51. Folate-mediated targeting: from diagnostics to drug and gene delivery. Leamon CP(1), Low PS. Author information: (1)Endocyte Pharmaceuticals, 1205 Kent Avenue, 47906, West Lafayette, IN, USA The covalent attachment of the vitamin folic acid to almost any molecule yields a conjugate that can be endocytosed into folate …Author: Christopher P. Leamon, Philip S. Low
https://www.researchgate.net/publication/12165212_Folate-mediated_targeting_From_diagnostics_to_drug_and_gene_delivery
The folate receptor (FR) is a single chain cell-surface glycoprotein that binds folic acid and mediates uptake of the vitamin. As FRs are significantly overexpressed in the majority of cancer...
http://europepmc.org/abstract/MED/11165172
Feb 01, 2001 · Phase I and II clinical studies for the first folate-containing imaging agent were initiated in 1999, and clinical trials of folate-targeted therapeutic agents should soon follow. This review will summarize folate-mediated drug delivery and highlight those techniques undergoing active preclinical or clinical investigation.Author: Christopher P. Leamon, Philip S. Low
https://onlinelibrary.wiley.com/doi/abs/10.1002/jps.20457
Aug 31, 2005 · Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its small molecular size and high binding affinity for cell surface folate receptors (FR), folate conjugates have the ability to deliver a variety of molecular complexes to pathologic cells without causing harm to normal tissues.Author: Andrew R. Hilgenbrink, Philip S. Low
http://onlinelibrary.wiley.com/doi/10.1002/jps.20457/abstract
Aug 31, 2005 · Folate receptor-mediated drug targeting: From therapeutics to diagnostics. Authors. Andrew R. Hilgenbrink, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 ... Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its small ...
https://www.dovepress.com/folate-mediated-targeted-delivery-of-siplk1-by-leucine-bearing-polyeth-peer-reviewed-fulltext-article-IJN
Hartono SB, Phuoc NT, Yu M, et al. Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery. J Mater Chem B. 2014;2(6):718–726. 10. Leamon CP, Low PS. Folate-mediated targeting: from diagnostics to drug and gene delivery.Author: Lu Hou, Zheyu Song, Zhonghang Xu, Yuanyu Wu, Wei Shi
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