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https://healthinfoispower.files.wordpress.com/2009/10/folate-receptor.pdf
Folate receptor-targeted anti-cancer agent delivery Despite the fact that there have been significant developments in anti-cancer technology, such as radiotherapy, chemotherapy and hormone therapy, cancer still remains as the second leading cause of death following heart disease in the United States (1). Most often, the main
https://www.hindawi.com/journals/bmri/2014/814208/
Targeted delivery systems of nanobiomaterials are necessary to be developed for the diagnosis and treatment of cancer. Nanobiomaterials can be engineered to recognize cancer-specific receptors at the cellular levels and to deliver anticancer drugs into the diseased sites. In particular, nanobiomaterial-based nanocarriers, so-called nanoplatforms, are the design of the targeted delivery systems ...Author: Su-Eon Jin, Hyo-Eon Jin, Soon-Sun Hong
https://www.ncbi.nlm.nih.gov/pubmed/16296717
Tumour cell-targeted liposomal delivery has the potential to enhance the therapeutic efficacy and reduce the toxicity of anticancer agents. Folate receptor (FR) expression is frequently amplified among human malignancies. FR is, therefore, potentially useful as a tumour marker for targeted drug delivery.Author: Xiaogang Pan, Robert J Lee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521101/
Dec 07, 2012 · Folate and the folate receptor. The folate receptor, a glycosylphosphatidylinositol anchored cell surface receptor, is overexpressed on the vast majority of cancer tissues, while its expression is limited in healthy tissues and organs ().Folate receptors are highly expressed in epithelial, ovarian, cervical, breast, lung, kidney, colorectal, and brain tumors (10, 11).Author: Grant L. Zwicke, G. Ali Mansoori, Constance J. Jeffery
https://mct.aacrjournals.org/content/molcanther/15/2/221.full.pdf
Folate Receptor–Targeted Polymeric Micellar ... NPs for delivery of the hydrophobic anitobesity drug orlistat as a repurposed anticancer agent against TNBC. Since the folate receptor is specific to TNBC, we use folic acid conjugation of these micellar NPs to selectively target TNBC cells. OrlistatAuthor: Ramasamy Paulmurugan, Rohith Bhethanabotla, Kaushik Mishra, Rammohan Devulapally, Kira Foygel, Thill...
https://pubs.acs.org/doi/abs/10.1021/ie9011479
Jan 27, 2010 · Doxorubicin-loaded nanocarriers were produced employing folate-modified polyethylene glycol (PEG)-functionalized gold nanoparticles for targeted delivery to positive folate-receptor cancer cells. Doxorubicin and folate were, respectively, conjugated to activated-folate and activated-PEG. The conjugates formed doxorubicin nanocarrier with an average size of 12 nm in diameter. The drug …Author: Bahareh Asadishad, Manouchehr Vossoughi, Iran Alemzadeh
https://pubs.acs.org/doi/10.1021/acsomega.9b00554
Phase I and II clin. studies for the 1st folate-contg. imaging agent were initiated in 1999, and clin. trials of folate-targeted therapeutic agents should soon follow. This review will summarize folate-mediated drug delivery and highlight those techniques undergoing active preclin. or clin. investigation.Author: Menghui Zhao, Yaxin Cui, Lang Zhao, Tianyu Zhu, Robert J. Lee, Weiwei Liao, Fengying Sun, Youxin Li,...
https://www.sciencedirect.com/science/article/pii/S0168365916307301
Presently, there have been multiple promising Phase II clinical trials using the folate receptor-targeted chemotherapeutic agent vintafolide in combination with a FR-targeted companion SPECT imaging agent (99 m) Tc-etarfolatide for the treatment of ovarian cancer , . However, our study may be the first to examine FR-mediated intracellular ...Author: Joseph P. Marshalek, Paul S. Sheeran, Paul S. Sheeran, Pier Ingram, Paul A. Dayton, Russell S. Witte...
https://www.sciencedirect.com/science/article/pii/S0928098715300610
Characterization and evaluation of a folic acid receptor-targeted cyclodextrin complex as an anticancer drug delivery system. ... Folic acid receptor-targeted cyclodextrin(FA-CD) Drug delivery system(DDS) ... the novel FR-targeted cyclodextrin complex is a promising anticancer drug delivery system.Author: Jiaojiao Xu, Beihua Xu, Dan Shou, Fuhua Qin, Yong Xu, Ying Hu
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