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https://cen.acs.org/business/start-ups/Meet-exosome-rising-star-drug/96/i31
Meet the exosome, the rising star in drug delivery Companies are hoping to use the vesicles to package small-molecule, protein, and RNA drugs or even use them as therapies themselves
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356169/
Mar 16, 2012 · Exosome-based drug delivery systems: biotechnological versus synthetic approaches. The successful use of exosomes for the targeted delivery of siRNA has been recently demonstrated by Alvarez- Erviti et al.53 They harvested dendritic cells from mice and transfected them to express the neuronal targeting ligand, RVG, coupled to the exosomal membrane protein, Lamp2b.Author: Sander Aa Kooijmans, Pieter Vader, Susan M van Dommelen, Wouter W van Solinge, Raymond M Schiffelers
https://www.nature.com/articles/aps201712
Apr 10, 2017 · Thus, exosome delivery can bypass the P-glycoprotein (P-gp) drug efflux system. However, the exosomes themselves do not inhibit P-gp, and the mechanism …Author: Xin Luan, Kanokwan Sansanaphongpricha, Ila Myers, Hongwei Chen, Hebao Yuan, Duxin Sun
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951582/
Mar 08, 2016 · In these cases, exosomes or exosome mimetics50—with many of the desirable features of an ideal drug delivery system, such as a long circulating half-life, the intrinsic ability to target tissues, biocompatibility, and minimal or no inherent toxicity issues51—appear to be a superior choice, overcoming the limitations observed with the ...Author: Dinh Ha, Ningning Yang, Venkatareddy Nadithe
https://www.sciencedirect.com/science/article/pii/S0734975012001474
However, DC exosomes are immunogenic and their use as drug delivery vehicles would require the use of immune-compatible exosomes. Therefore, an ideal cell source of exosome for drug delivery would be one that produces an abundance of non-immunogenic exosomes.Author: Ruenn Chai Lai, Ronne Wee Yeh Yeo, Ronne Wee Yeh Yeo, Kok Hian Tan, Sai Kiang Lim
https://www.sciencedirect.com/science/article/pii/S037851731730128X
Exosome delivery to recipient cells is a key step in mediating changes in cellular behavior (Lakhal and Wood, 2011, Vallhov et al., 2011). In addition, they also play essential roles in intercellular communication (Zhang and Chopp, 2016). For these natural characteristics, exosomes are being explored as drug and gene delivery vehicles.Author: Xin-Chi Jiang, Jian-Qing Gao
https://exopharm.com/exosomes-as-drug-delivery-vehicles/
Jan 01, 2017 · Exopharm’s LEAP technology actually purifies exosomes and is ideally suited to large-scale biomanufacturing processing. Exosomes purified by the LEAP technology are called Exomeres ™ – exosomes ideally suited for targeted exosome drug delivery or as a stem cell derived drug.
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0403-9
Oct 16, 2018 · This exosome is suitable for drug delivery for brain treatment since it has better ability to cross the BBB compared to other nanotechnology. In another hand, Metastatic cancer cell-derived exosomes, MM-exosomes, and PCC-exosomes are useful properties for cancer treatment as these exosomes have an important role in cancer cell maintenance that ...Author: Edwin J. Bunggulawa, Wei Wang, Tieying Yin, Nan Wang, Colm Durkan, Yazhou Wang, Guixue Wang
https://www.exosome-rna.com/tag/drug-delivery/
Aug 22, 2019 · Aethlon Medical Alzheimer's disease angiogenesis biomarker biomarkers breast cancer cancer Circulating tumor cells Drug delivery exosomal rna exosome Exosome Diagnostics exosome isolation exosome rna Exosomes extracellular vesicle extracellular vesicles flow cytometry intercellular communication isolation liquid biopsies Liquid Biopsy Lung ...
https://www.youtube.com/watch?v=9UMOV3tvFuk
Aug 17, 2018 · In this video for Evox Therapeutics we explore how exosomes - the body's own delivery system - can be used to deliver drugs in a precise, targeted way. For more information, please visit: https ...
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