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https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Examples of anticipated results in which exosome-mediated siRNA delivery is evaluated by functional assays and imaging are also provided. The entire protocol takes ∼3 weeks.Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://cen.acs.org/business/start-ups/Meet-exosome-rising-star-drug/96/i31
Meet the exosome, the rising star in drug delivery Companies are hoping to use the vesicles to package small-molecule, protein, and RNA drugs or even use them as therapies themselves
https://www.sciencedirect.com/science/article/pii/S2162253117301609
Focal BBB disruption may also facilitate the cross of RVG-Exos at the infarct site, making RVG-Exos effective drug delivery tools for ischemia treatment. Notably, most of the ischemic area was DiI positive in the RVG-exosome delivery group, suggesting that besides neurons, astrocytes and endothelial cells might be also the recipient cells.Author: Jialei Yang, Jialei Yang, Xiufen Zhang, Xiangjie Chen, Lei Wang, Guodong Yang
https://www.ncbi.nlm.nih.gov/pubmed/31830541
Dec 09, 2019 · Herein, we identify exosomes from autologous breast cancer cells that show effective lung targeting ability. Based on this, we developed the biomimetic nanoparticles (cationic bovine serum albumin (CBSA) conjugated siS100A4 and exosome membrane coated nanoparticles, CBSA/siS100A4@Exosome) to improve drug delivery to the lung PMN.Author: Liuwan Zhao, Chunyan Gu, Ye Gan, Lanlan Shao, Hongwei Chen, Hongyan Zhu
https://www.sciencedirect.com/science/article/pii/S037851731730128X
Exosome delivery to recipient cells is a key step in mediating changes in cellular behavior (Lakhal and Wood, 2011, Vallhov et al., 2011). In addition, they also play essential roles in intercellular communication (Zhang and Chopp, 2016). For these natural characteristics, exosomes are being explored as drug and gene delivery vehicles.Author: Xin-Chi Jiang, Jian-Qing Gao
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00901
The effective delivery of target-specific siRNA to the brain by exploiting the exosomes derived from dendritic cells renders the paradigm shift for the prospective use of nanosized exosomes as a delivery system. Although the in vivo targeting strategies by other nanovesicles like liposomes exist, still this novel exosome-based delivery approach holds an inclusive dominance of in vivo security ...Author: Chandan Kanta Das, Bikash Chandra Jena, Indranil Banerjee, Subhayan Das, Aditya Parekh, Sujit Kumar ...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0403-9
Oct 16, 2018 · An exosome-based delivery system has particular benefits such as specificity, safety, and stability. By their homing characteristic, exosomes can deliver their cargo to specific targets over a long distance. Exosomes can also be used to deliver interfering RNA (siRNA) or pharmaceutically active substances . As exosomes are small and native to ...Author: Edwin J. Bunggulawa, Wei Wang, Tieying Yin, Nan Wang, Colm Durkan, Yazhou Wang, Guixue Wang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112038/
Aug 09, 2016 · To assess whether exosome-mediated hsiRNA HTT delivery productively silences Htt mRNA and protein, we treated mouse primary cortical neurons for 7 days with increasing doses of hsiRNA HTT-loaded exosomes (Figure 3). As a negative control, cells were treated with exosomes loaded with nontargeting hsiRNA NTC.Author: Marie-Cécile Didiot, Lauren M Hall, Andrew H Coles, Reka A Haraszti, Bruno Mdc Godinho, Kathryn Chas...
https://www.nature.com/articles/aps201712
Apr 10, 2017 · Thus, exosome delivery can bypass the P-glycoprotein (P-gp) drug efflux system. However, the exosomes themselves do not inhibit P-gp, and the mechanism by which they overcome the drug resistance ...Author: Xin Luan, Kanokwan Sansanaphongpricha, Ila Myers, Hongwei Chen, Hebao Yuan, Duxin Sun
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