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https://www.sciencedirect.com/science/article/pii/S0168365918301202
Additional polymer and polyplex engineering would be required to create a gene delivery platform for in vivo delivery to prevent non-specific interactions and toxicities caused by the positive charges on the surface of the polyplex. However, the flexible cargo loading of this polymer system makes it attractive for ex vivo gene delivery ...Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://www.sciencedirect.com/science/article/pii/S016777991830060X
Gene delivery mediated by polymeric vectors is a multistage process. It involves multiple obstacles to overcome before the nucleic acid material can reach the target site (Figure 1, Key Figure).The target site here refers to the cytosol for RNA molecules and the nucleus for plasmids.Author: Wing-Fu Lai, Wing-Fu Lai, Wing-Tak Wong
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
To overcome the barriers of gene delivery, different types of non-viral delivery systems, including polymers, have been developed and advanced to clinical trials. Manuscripts addressing the design, synthesis, and characterization of polymer-based gene delivery systems are solicited.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147627/
Jan 31, 2005 · Nonviral delivery systems. The nonviral systems developed for gene delivery include: (1) Direct DNA delivery — Direct DNA delivery entails direct injection of DNA (naked DNA) into the target organ. This method was useful in delivery of DNA into skeletal muscle [11,12], liver [], heart muscle [], and tumors [].However, naked DNA goes through rapid degradation upon systemic administration.Author: H. Eliyahu, Y. Barenholz, A. J. Domb
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/biopolymer-in-gene-delivery
Nowadays, biopolymers, a class of biomaterials, represent frontier area in the drug delivery systems. Drug release from nano- and microparticles is a complex process, which involves several steps. Uptake of nanoparticle in the intracellular is affected by numerous factors. Recently, gene delivery has been considered one of the promising approaches for the treatment of various diseases acquired ...Author: Sakthivel Lakshmana Prabu, Kandasamy Ruckmani
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079258/
Mar 01, 2011 · Bioreducible polymers, which possess mainly disulfide linkages in the polymer structures, have appeared as ideal gene delivery carriers due to the high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as decreased cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules ...Author: Tae Il Kim, Sung Wan Kim, Sung Wan Kim
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · With growing understanding of polymer gene delivery mechanisms and continued efforts of creative and talented polymer chemists, it is likely that polymer-based …Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://www.pnas.org/content/98/3/1200
Jan 30, 2001 · Protein expression after delivery of plasmid DNA to the cell nucleus depends on the processes of transcription and translation. Cytotoxic gene-delivery systems may compromise these processes and limit protein expression. This situation is perhaps most prevalent in current nonviral polycationic gene-delivery systems in which the polycationic nature of the delivery system can lead to ...Author: David Putnam, Christine A. Gentry, Daniel W. Pack, Robert Langer
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