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https://www.sciencedirect.com/science/article/pii/S1359644613002006
To improve the efficiency of polymer gene delivery to the level seen in viral vectors, it is necessary to understand the challenges faced by polymer gene delivery vectors both in vitro and in vivo. In this review, we analyse and discuss those obstacles that scientists have to overcome to design a highly efficient synthetic transfection agent.Author: Ahmed Aied, Udo Greiser, Abhay Pandit, Wenxin Wang
https://www.ncbi.nlm.nih.gov/pubmed/23831858
To improve the efficiency of polymer gene delivery to the level seen in viral vectors, it is necessary to understand the challenges faced by polymer gene delivery vectors both in vitro and in vivo. In this review, we analyse and discuss those obstacles that scientists have to overcome to design a highly efficient synthetic transfection agent.Author: Ahmed Aied, Udo Greiser, Abhay Pandit, Wenxin Wang
https://www.researchgate.net/publication/247156850_Polymer_gene_delivery_Overcoming_the_obstacles
Peptides demonstrate various functions in polymer-based gene delivery systems, such as targeting to specific cells, breaching membrane barriers, facilitating DNA condensation and release, and ...
https://www.academia.edu/14008484/Polymer_gene_delivery_overcoming_the_obstacles
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https://www.deepdyve.com/lp/elsevier/polymer-gene-delivery-overcoming-the-obstacles-mAn6zsbCNb
Nov 01, 2013 · Read "Polymer gene delivery: overcoming the obstacles, Drug Discovery Today" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.sciencedirect.com/book/9780081005200/polymers-and-nanomaterials-for-gene-therapy
Abstract. Polyethyleneimine (PEI) is a cationic polymer used as a gold standard in non-viral gene delivery. The extraordinary cationic charge and buffering capacity of the PEI has been beneficial for complexation with nucleic acids (DNA/RNA) and endosomal/lysosomal …
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do …Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://pubs.acs.org/doi/10.1021/bc2005472
Cellular uptake and nuclear localization are two major barriers in gene delivery. In order to evaluate whether additional nuclear localization signals (NLSs) can improve gene transfection efficiency, we introduced different kinds of NLSs to TAT-based gene delivery systems to form three kinds of complexes, including TAT-PV/DNA, TAT/DNA/PV, and TAT/DNA/HMGB1. The DNA binding ability of different ...
https://www.researchgate.net/publication/295351425_Nano-materials_for_Gene_Therapy_An_Efficient_Way_in_Overcoming_Challenges_of_Gene_Delivery
Dec 28, 2015 · Nano-materials for Gene Therapy: An Efficient Way in Overcoming Challenges of Gene Delivery Article (PDF Available) · December 2015 with 387 Reads How we measure 'reads'
https://pubs.acs.org/doi/10.1021/bc9003662
Polymer gene delivery: overcoming the obstacles. Drug Discovery Today 2013, 18 (21-22) , 1090-1098. DOI: 10.1016/j.drudis.2013.06.014. Hamideh Parhiz, Wayne Thomas Shier, Mohammad Ramezani. From rationally designed polymeric and peptidic systems to sophisticated gene delivery nano-vectors.
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