Polymer Gene Delivery Review

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Recent Advances in Nanomaterials for Gene Delivery—A Review

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
    Apr 28, 2017 · 6. Polymer-Based Nanomaterials for Gene Delivery. Both natural and synthetic polymers display variation in structure (e.g., linear or branched), and molecular weight, that together with the chemical properties of the repeat unit(s), affect their physico-chemical properties.Author: Michael K. Riley, Wilfred Vermerris

Design and development of polymers for gene delivery ...

    https://www.nature.com/articles/nrd1775
    Jul 01, 2005 · With growing understanding of polymer gene delivery mechanisms and continued efforts of creative and talented polymer chemists, it is likely that polymer-based …Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton

Design of Polymeric Gene Carriers for Effective ...

    https://www.sciencedirect.com/science/article/pii/S016777991830060X
    A thorough understanding of these cellular impediments is pivotal to optimizing the efficiency of polymer-based gene delivery. This review delineates the major barriers encountered during intracellular delivery of polyplexes and discusses possible molecular designs to overcome these barriers.Author: Wing-Fu Lai, Wing-Fu Lai, Wing-Tak Wong

Recent advances in the development of gene delivery systems

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
    Mar 12, 2019 · Gene delivery systems are essentially necessary for the gene therapy of human genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to cure any disease. The gene therapy is one of promising therapies for a number of ...Author: YK Sung, SW Kim

Polymer gene delivery: overcoming the obstacles ...

    https://www.sciencedirect.com/science/article/pii/S1359644613002006
    To improve the efficiency of polymer gene delivery to the level seen in viral vectors, it is necessary to understand the challenges faced by polymer gene delivery vectors both in vitro and in vivo. In this review, we analyse and discuss those obstacles that scientists have to overcome to design a highly efficient synthetic transfection agent.Author: Ahmed Aied, Udo Greiser, Abhay Pandit, Wenxin Wang

Polymers Special Issue : Polymers in Gene Delivery

    https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
    To overcome the barriers of gene delivery, different types of non-viral delivery systems, including polymers, have been developed and advanced to clinical trials. Manuscripts addressing the design, synthesis, and characterization of polymer-based gene delivery systems are solicited.

Synthetic materials at the forefront of gene delivery ...

    https://www.nature.com/articles/s41570-018-0039-1
    Sep 21, 2018 · In this Review, the authors discuss the latest developments in synthetic materials used for gene delivery and the challenges that must be overcome to transfer these innovations into the clinic ...Author: Irene Lostalé-Seijo, Javier Montenegro

Cationic Polymer Based Gene Delivery Systems SpringerLink

    https://link.springer.com/article/10.1023%2FA%3A1007548826495
    Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink

Polymeric Nanoparticle-Mediated Gene Delivery for Lung ...

    https://link.springer.com/article/10.1007/s41061-017-0128-5
    Mar 13, 2017 · This review highlights the recent developments in gene delivery using synthetic and natural polymer-based nucleic acid carriers for lung cancer treatment. Various nanoparticle systems based on polymers and polymer combinations are discussed.Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi, Rajagopal Ramesh

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