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https://www.ncbi.nlm.nih.gov/pubmed/27547843
Oct 19, 2016 · This process is known as the enhanced permeability and retention (EPR) effect. However, while the EPR effect is widely held to improve delivery of nanodrugs to tumors, it in fact offers less than a 2-fold increase in nanodrug delivery compared with critical normal organs, resulting in drug concentrations that are not sufficient for curing most ...Author: Yuko Nakamura, Ai Mochida, Peter L. Choyke, Hisataka Kobayashi
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/63/issue/3
Mar 18, 2011 · The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Jun Fang, Hideaki Nakamura, Hiroshi Maeda Pages 136 …
https://www.sciencedirect.com/science/article/pii/S0169409X10000906
The EPR effect has thus now become the “gold standard” in anticancer drug design and anticancer strategies using macromolecular agents, including gene delivery, molecular imaging, antibody therapy, micelles, liposomes, and protein–polymer conjugates (see Torchilin in this issue of ADDR). As evidence of this status, the numbers of citations related to the EPR effect have been ...Author: Jun Fang, Hideaki Nakamura, Hiroshi Maeda
https://www.ncbi.nlm.nih.gov/pubmed/20441782
Mar 18, 2011 · The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Fang J(1), Nakamura H, Maeda H. Author information: (1)Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.Author: Jun Fang, Hideaki Nakamura, Hiroshi Maeda
https://whatisnanomedicine.com/tag/epr-effect/
To read more about the controversy surrounding the EPR effect, this review paper by Deinheir is quite good To exploit the tumour microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?. So, now we know how nanoparticles can be used in nanomedicine to target specific cells and enter inside them.
https://www.nature.com/articles/s41467-018-03705-y
Apr 12, 2018 · There is also limited patient-based experimental data on the EPR phenomenon itself and its effect on drug accumulation in the ... hybrid approaches combining local drug delivery with other ...Author: Daniel Rosenblum, Nitin Joshi, Nitin Joshi, Wei Tao, Jeffrey M. Karp, Jeffrey M. Karp, Dan Peer
https://www.nature.com/articles/s41598-017-09815-9
Aug 24, 2017 · A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems Skip to main content Thank you for visiting nature.com.Author: Yuan Tang, Fariborz Soroush, Joel B. Sheffield, Bin Wang, Bin Wang, Balabhaskar Prabhakarpandian, Mo...
https://link.springer.com/chapter/10.1007%2F978-1-4614-7876-8_23
Jul 10, 2013 · The EPR effect has been considered as an alternative method for delivery of conventional anticancer drugs, and favorable bio-distribution of cancer therapeutic nanoparticles in blood would be considered to achieve a high level of accumulation in solid tumors.Author: Ji Young Yhee, Sejin Son, Sohee Son, Min Kyung Joo, Ick Chan Kwon
https://www.azonano.com/article.aspx?ArticleID=4668
Nov 01, 2017 · The application of nanotechnology for drug delivery provides the potential for enhanced treatments with targeted delivery and fewer side effects. Nanotechnology drug delivery applications occur through the use of designed nanomaterials as well as forming delivery systems from nanoscale molecules such as liposomes.Author: Azonano
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