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https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/63/issue/3
Mar 18, 2011 · The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Jun …
https://www.sciencedirect.com/science/article/pii/S0169409X12003201
Fig. 2 presents the various steps involved in drug delivery to tumor tissues and then to tumor cells, and they are the barriers that must be overcome in cancer drug development. The EPR effect, at the first step, is of prime importance because drug extravasation occurs in a tumor-selective manner.Author: Hiroshi Maeda, Hideaki Nakamura, Jun Fang
https://www.ncbi.nlm.nih.gov/pubmed/20441782
Mar 18, 2011 · The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Fang J(1), Nakamura H, Maeda H. Author information: (1)Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.Author: Jun Fang, Hideaki Nakamura, Hiroshi Maeda
https://www.ncbi.nlm.nih.gov/pubmed/27547843
Oct 19, 2016 · This process is known as the enhanced permeability and retention (EPR) effect. However, while the EPR effect is widely held to improve delivery of nanodrugs to tumors, it in fact offers less than a 2-fold increase in nanodrug delivery compared with critical normal organs, resulting in drug concentrations that are not sufficient for curing most cancers.Author: Yuko Nakamura, Ai Mochida, Peter L. Choyke, Hisataka Kobayashi
https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.6b00437
However, while the EPR effect is widely held to improve delivery of nanodrugs to tumors, it in fact offers less than a 2-fold increase in nanodrug delivery compared with critical normal organs, resulting in drug concentrations that are not sufficient for curing most cancers.Author: Yuko Nakamura, Ai Mochida, Peter L. Choyke, Hisataka Kobayashi
https://cancerres.aacrjournals.org/content/73/8/2412
Apr 15, 2013 · The EPR effect for macromolecular drug delivery to solid tumors: improved tumor uptake, less systemic toxicity, and improved tumor imaging ―Review of the vascular permeability of tumors and the EPR effect.Author: Uma Prabhakar, Hiroshi Maeda, Rakesh K. Jain, Eva M. Sevick-Muraca, William Zamboni, Omid C. Farokhz...
https://www.nature.com/articles/s41467-018-03705-y
Apr 12, 2018 · Evaluation of 11 dogs bearing spontaneous solid tumors revealed that while the EPR effect is a predominant feature in few solid tumors (e.g., …Author: Daniel Rosenblum, Nitin Joshi, Nitin Joshi, Wei Tao, Jeffrey M. Karp, Jeffrey M. Karp, Dan Peer
https://link.springer.com/chapter/10.1007%2F978-1-4614-7876-8_23
Jul 10, 2013 · The EPR effect has been considered as an alternative method for delivery of conventional anticancer drugs, and favorable bio-distribution of cancer therapeutic nanoparticles in blood would be considered to achieve a high level of accumulation in solid tumors.Author: Ji Young Yhee, Sejin Son, Sohee Son, Min Kyung Joo, Ick Chan Kwon
https://www.nature.com/articles/s41598-017-09815-9
Aug 24, 2017 · A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems Skip to main content Thank you for visiting nature.com.Author: Yuan Tang, Fariborz Soroush, Joel B. Sheffield, Bin Wang, Bin Wang, Balabhaskar Prabhakarpandian, Mo...
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