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https://drug-dev.com/lipid-based-delivery-are-lipid-based-drug-delivery-systems-in-your-formulation-toolbox/
Lipid-based drug delivery systems (LBDDS) is a wide-ranging designation for formulations containing a dissolved or suspended drug in lipidic excipients. Lipids are esters of fatty acids – lipophilic hydrocarbon chains linked to a hydrophilic group like glycerol, polyglycerol, or polyalcohol (Figure 1).
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/lipid-based-drug-delivery-system
Lipid-based drug delivery systems showed great potential in overcoming problems of low bioavailability of poorly soluble drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142081/
Sep 28, 2014 · 1.1 Synthetic lipids for drug delivery There are three key steps in liposomal drug delivery that can be improved with synthetic lipids: 1) extended circulation of the liposome after intravenous administration, 2) directed lipid headgroup interactions and cell targeting and 3) controlled payload release (Figure 2, ,3). 3).Author: Aditya G. Kohli, Aditya G. Kohli, Paul H. Kierstead, Vincent J. Venditto, Colin L. Walsh, Colin L. W...
https://www.hindawi.com/journals/jphar/2014/801820/
The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs.Author: Kent Jørgensen, Jesper Davidsen, Charlotte Vermehren, Sven Frøkjær, Ole G. Mouritsen
https://www.sciencedirect.com/science/article/pii/S2211383513000919
Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address such challenges. Encapsulating or solubilizing the drug in lipid excipients can lead to increased solubilization and absorption, resulting in enhanced bioavailability.Author: Sandeep Kalepu, Mohanvarma Manthina, Veerabhadhraswamy Padavala
https://www.ncbi.nlm.nih.gov/pubmed/30064267
Solid lipid nanocarriers in drug delivery: characterization and design. Mu H(1), Holm R(2). Author information: (1)a Department of Pharmacy, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark. (2)b Drug Product Development , Janssen Research and Development , Beerse , Belgium.Author: Huiling Mu, René Holm
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/lipid-nanoparticulate-drug-delivery-systems-a-revolution-in-dosage-form-design-and-development
In many biological systems, the major lipids are non-bilayer lipids, which in purified form cannot be arranged in a lamellar structure in the presence of aqueous systems. The structural and functional roles of these lipids in drug delivery are mainly in their utilization as matrix-forming lipids.Author: Anthony A. Attama, Mumuni A. Momoh, Philip F. Builders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885142/
Design principle of an ideal multifunctional lipid-based nanoparticle for targeted and triggered drug delivery. Liposomes consist of a matrix phospholipid (cyan), a destabilizing (pore forming) phospholipid (yellow), conjugation lipid (green), ligand ...Author: Anu Puri, Kristin Loomis, Brandon Smith, Jae-Ho Lee, Amichai Yavlovich, Eliahu Heldman, Robert Blume...
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