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https://www.sciencedirect.com/science/article/pii/S0169409X96004231
advanced drug delivery reviews ELSEVIER Advanced Drug Delivery Reviews 23 (1997) 3-25 Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Christopher A. Lipinski*, Franco Lombardo, Beryl W. Dominy, Paul J. Feeney Central Research Division, Pfizer Inc..Author: Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy, Paul J. Feeney
https://www.ncbi.nlm.nih.gov/pubmed/11259830
Mar 01, 2001 · Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described. In the discovery setting 'the rule of 5' predicts that poor absorption or permeation is more likely when there …Author: Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy, Paul J. Feeney
https://www.meliordiscovery.com/wp-content/uploads/2019/09/Rule-of-five-in-2015-and-beyond-Target-and-ligand-structural-limitations-ligand-chemistry-structure-and-drug-discovery-project-decisions-article-in-press.pdf
Advanced Drug Delivery Reviews xxx (2016) xxx–xxx ... 2 C.A. Lipinski / Advanced Drug Delivery Reviews xxx (2016) xxx–xxx Please cite this article as: C.A. Lipinski, Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and
http://moglen.law.columbia.edu/twiki/pub/LawNetSoc/BahradSokhansanjFirstPaper/46AdvDrugDisc3_Lipinski_rule_of_five_2001.pdf
C.A.Lipinski et al. / Advanced Drug Delivery Reviews 46 (2001) 3–26 5 This situation changed dramatically about 1989– problems related to poor compound solubility are 1991. Prior to 1989, it was technically unfeasible to often compensated for by the follow-up to the screen for in vitro activity across hundreds of primary screen.
https://www.journals.elsevier.com/advanced-drug-delivery-reviews/
The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad... Menu. Search. Search. Search in: All. Webpages. Books. ... The latest Open Access articles published in Advanced Drug Delivery Reviews.
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